Application of a phenotypic drug discovery strategy to identify biological and chemical starting points for inhibition of TSLP production in lung epithelial cells

Thymic stromal lymphopoietin (TSLP) is a cytokine released by human lung epithelium in response to external insult. Considered as a master switch in T helper 2 lymphocyte (Th2) mediated responses, TSLP is believed to play a key role in allergic diseases including asthma. The aim of this study was to...

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Detalles Bibliográficos
Autores principales: Orellana, Adelina, García-González, Vicente, López, Rosa, Pascual-Guiral, Sonia, Lozoya, Estrella, Díaz, Julia, Casals, Daniel, Barrena, Antolín, Paris, Stephane, Andrés, Miriam, Segarra, Victor, Vilella, Dolors, Malhotra, Rajneesh, Eastwood, Paul, Planagumà, Anna, Miralpeix, Montserrat, Nueda, Arsenio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761851/
https://www.ncbi.nlm.nih.gov/pubmed/29320511
http://dx.doi.org/10.1371/journal.pone.0189247

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