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Characterization of the naive murine antibody repertoire using unamplified high-throughput sequencing

Antibody specificity and diversity are generated through the enzymatic splicing of genomic gene segments within each B cell. Antibodies are heterodimers of heavy- and light-chains encoded on separate loci. We studied the antibody repertoire from pooled, splenic tissue of unimmunized, adult female C5...

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Detalles Bibliográficos
Autores principales:	Rettig, Trisha A., Ward, Claire, Bye, Bailey A., Pecaut, Michael J., Chapes, Stephen K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761896/ https://www.ncbi.nlm.nih.gov/pubmed/29320559 http://dx.doi.org/10.1371/journal.pone.0190982

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