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Antioxidant Supplementation: A Linchpin in Radiation-Induced Enteritis

Radiation enteritis is one of the most feared complications of abdominal and pelvic regions. Thus, radiation to abdominal or pelvic malignancies unavoidably injures the intestine. Because of rapid cell turnover, the intestine is highly sensitive to radiation injury, which is the limiting factor in t...

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Autores principales: Anwar, Mumtaz, Ahmad, Shabeer, Akhtar, Reyhan, Mahmood, Akhtar, Mahmood, Safrun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762044/
https://www.ncbi.nlm.nih.gov/pubmed/28532242
http://dx.doi.org/10.1177/1533034617707598
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author Anwar, Mumtaz
Ahmad, Shabeer
Akhtar, Reyhan
Mahmood, Akhtar
Mahmood, Safrun
author_facet Anwar, Mumtaz
Ahmad, Shabeer
Akhtar, Reyhan
Mahmood, Akhtar
Mahmood, Safrun
author_sort Anwar, Mumtaz
collection PubMed
description Radiation enteritis is one of the most feared complications of abdominal and pelvic regions. Thus, radiation to abdominal or pelvic malignancies unavoidably injures the intestine. Because of rapid cell turnover, the intestine is highly sensitive to radiation injury, which is the limiting factor in the permissible dosage of irradiation. Bowel injuries such as fistulas, strictures, and chronic malabsorption are potentially life-threatening complications and have an impact on patient quality of life. The incidence of radiation enteritis is increasing because of the current trend of combined chemotherapy and radiation. The consequences of radiation damage to the intestine may result in considerable morbidity and even mortality. The observed effects of ionizing radiation are mediated mainly by oxygen-free radicals that are generated by its action on water and are involved in several steps of signal transduction cascade, leading to apoptosis. The oxyradicals also induce DNA strand breaks and protein oxidation. An important line of defense against free radical damage is the presence of antioxidants. Therefore, administration of antioxidants may ameliorate the radiation-induced damage to the intestine.
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spelling pubmed-57620442018-01-17 Antioxidant Supplementation: A Linchpin in Radiation-Induced Enteritis Anwar, Mumtaz Ahmad, Shabeer Akhtar, Reyhan Mahmood, Akhtar Mahmood, Safrun Technol Cancer Res Treat Reviews Radiation enteritis is one of the most feared complications of abdominal and pelvic regions. Thus, radiation to abdominal or pelvic malignancies unavoidably injures the intestine. Because of rapid cell turnover, the intestine is highly sensitive to radiation injury, which is the limiting factor in the permissible dosage of irradiation. Bowel injuries such as fistulas, strictures, and chronic malabsorption are potentially life-threatening complications and have an impact on patient quality of life. The incidence of radiation enteritis is increasing because of the current trend of combined chemotherapy and radiation. The consequences of radiation damage to the intestine may result in considerable morbidity and even mortality. The observed effects of ionizing radiation are mediated mainly by oxygen-free radicals that are generated by its action on water and are involved in several steps of signal transduction cascade, leading to apoptosis. The oxyradicals also induce DNA strand breaks and protein oxidation. An important line of defense against free radical damage is the presence of antioxidants. Therefore, administration of antioxidants may ameliorate the radiation-induced damage to the intestine. SAGE Publications 2017-05-22 2017-12 /pmc/articles/PMC5762044/ /pubmed/28532242 http://dx.doi.org/10.1177/1533034617707598 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Reviews
Anwar, Mumtaz
Ahmad, Shabeer
Akhtar, Reyhan
Mahmood, Akhtar
Mahmood, Safrun
Antioxidant Supplementation: A Linchpin in Radiation-Induced Enteritis
title Antioxidant Supplementation: A Linchpin in Radiation-Induced Enteritis
title_full Antioxidant Supplementation: A Linchpin in Radiation-Induced Enteritis
title_fullStr Antioxidant Supplementation: A Linchpin in Radiation-Induced Enteritis
title_full_unstemmed Antioxidant Supplementation: A Linchpin in Radiation-Induced Enteritis
title_short Antioxidant Supplementation: A Linchpin in Radiation-Induced Enteritis
title_sort antioxidant supplementation: a linchpin in radiation-induced enteritis
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762044/
https://www.ncbi.nlm.nih.gov/pubmed/28532242
http://dx.doi.org/10.1177/1533034617707598
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