miR-7 Increases Cisplatin Sensitivity of Gastric Cancer Cells Through Suppressing mTOR

MicroRNAs have been reported to play an important role in diverse biological processes and cancer progression. MicroRNA-7 has been observed to be downregulated in human gastric cancer tissues, but the function of microRNA-7 in gastric cancer has not been well investigated. In this study, we demonstr...

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Autores principales: Xu, Ning, Lian, Yan-Jun, Dai, Xiang, Wang, Yuan-Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762063/
https://www.ncbi.nlm.nih.gov/pubmed/28693382
http://dx.doi.org/10.1177/1533034617717863
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author Xu, Ning
Lian, Yan-Jun
Dai, Xiang
Wang, Yuan-Jie
author_facet Xu, Ning
Lian, Yan-Jun
Dai, Xiang
Wang, Yuan-Jie
author_sort Xu, Ning
collection PubMed
description MicroRNAs have been reported to play an important role in diverse biological processes and cancer progression. MicroRNA-7 has been observed to be downregulated in human gastric cancer tissues, but the function of microRNA-7 in gastric cancer has not been well investigated. In this study, we demonstrate that the expression of microRNA-7 was significantly downregulated in 30 pairs of human gastric cancer tissues compared to adjacent normal tissues. Enforced expression of microRNA-7 inhibited cell proliferation and migration abilities of gastric cancer cells, BGC823 and SGC7901. Furthermore, microRNA-7 targeted mTOR in gastric cancer cells. In human clinical specimens, mTOR was higher expressed in gastric cancer tissues compared with adjacent normal tissues. More interestingly, microRNA-7 also sensitizes gastric cancer cells to cisplatin (CDDP) by targeting mTOR. Collectively, our results demonstrate that microRNA-7 is a tumor suppressor microRNA and indicate its potential application for the treatment of human gastric cancer in future.
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spelling pubmed-57620632018-01-17 miR-7 Increases Cisplatin Sensitivity of Gastric Cancer Cells Through Suppressing mTOR Xu, Ning Lian, Yan-Jun Dai, Xiang Wang, Yuan-Jie Technol Cancer Res Treat Original Articles MicroRNAs have been reported to play an important role in diverse biological processes and cancer progression. MicroRNA-7 has been observed to be downregulated in human gastric cancer tissues, but the function of microRNA-7 in gastric cancer has not been well investigated. In this study, we demonstrate that the expression of microRNA-7 was significantly downregulated in 30 pairs of human gastric cancer tissues compared to adjacent normal tissues. Enforced expression of microRNA-7 inhibited cell proliferation and migration abilities of gastric cancer cells, BGC823 and SGC7901. Furthermore, microRNA-7 targeted mTOR in gastric cancer cells. In human clinical specimens, mTOR was higher expressed in gastric cancer tissues compared with adjacent normal tissues. More interestingly, microRNA-7 also sensitizes gastric cancer cells to cisplatin (CDDP) by targeting mTOR. Collectively, our results demonstrate that microRNA-7 is a tumor suppressor microRNA and indicate its potential application for the treatment of human gastric cancer in future. SAGE Publications 2017-07-11 2017-12 /pmc/articles/PMC5762063/ /pubmed/28693382 http://dx.doi.org/10.1177/1533034617717863 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Articles
Xu, Ning
Lian, Yan-Jun
Dai, Xiang
Wang, Yuan-Jie
miR-7 Increases Cisplatin Sensitivity of Gastric Cancer Cells Through Suppressing mTOR
title miR-7 Increases Cisplatin Sensitivity of Gastric Cancer Cells Through Suppressing mTOR
title_full miR-7 Increases Cisplatin Sensitivity of Gastric Cancer Cells Through Suppressing mTOR
title_fullStr miR-7 Increases Cisplatin Sensitivity of Gastric Cancer Cells Through Suppressing mTOR
title_full_unstemmed miR-7 Increases Cisplatin Sensitivity of Gastric Cancer Cells Through Suppressing mTOR
title_short miR-7 Increases Cisplatin Sensitivity of Gastric Cancer Cells Through Suppressing mTOR
title_sort mir-7 increases cisplatin sensitivity of gastric cancer cells through suppressing mtor
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762063/
https://www.ncbi.nlm.nih.gov/pubmed/28693382
http://dx.doi.org/10.1177/1533034617717863
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