Antimicrobial and antiproliferative prospective of kosinostatin – a secondary metabolite isolated from Streptomyces sp.()

Cancer is a communal health hazard worldwide. The present investigation attempts to evaluate antimicrobial and anticancer potential of kosinostatin on mammary carcinoma cell line (MCF-7). The anticancer and antiproliferative activities of kosinostatin were analyzed on MCF cell line by MTT assay and...

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Detalles Bibliográficos
Autores principales: Rambabu, Vinayagam, Suba, Subramaniyan, Vijayakumar, Suburamaniyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762245/
https://www.ncbi.nlm.nih.gov/pubmed/29403952
http://dx.doi.org/10.1016/j.jpha.2014.11.002
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author Rambabu, Vinayagam
Suba, Subramaniyan
Vijayakumar, Suburamaniyan
author_facet Rambabu, Vinayagam
Suba, Subramaniyan
Vijayakumar, Suburamaniyan
author_sort Rambabu, Vinayagam
collection PubMed
description Cancer is a communal health hazard worldwide. The present investigation attempts to evaluate antimicrobial and anticancer potential of kosinostatin on mammary carcinoma cell line (MCF-7). The anticancer and antiproliferative activities of kosinostatin were analyzed on MCF cell line by MTT assay and cytotoxicity assays like lactate dehydrogenase (LDH) and glutathione (GSH). The secondary metabolite kosinostatin exhibited its apoptotic nature by expressing p53 protein. Collectively, the results acquired from this study promise that kosinostatin shows the potent anticancer activity.
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spelling pubmed-57622452018-02-05 Antimicrobial and antiproliferative prospective of kosinostatin – a secondary metabolite isolated from Streptomyces sp.() Rambabu, Vinayagam Suba, Subramaniyan Vijayakumar, Suburamaniyan J Pharm Anal Original Article Cancer is a communal health hazard worldwide. The present investigation attempts to evaluate antimicrobial and anticancer potential of kosinostatin on mammary carcinoma cell line (MCF-7). The anticancer and antiproliferative activities of kosinostatin were analyzed on MCF cell line by MTT assay and cytotoxicity assays like lactate dehydrogenase (LDH) and glutathione (GSH). The secondary metabolite kosinostatin exhibited its apoptotic nature by expressing p53 protein. Collectively, the results acquired from this study promise that kosinostatin shows the potent anticancer activity. Xi'an Jiaotong University 2015-12 2014-11-29 /pmc/articles/PMC5762245/ /pubmed/29403952 http://dx.doi.org/10.1016/j.jpha.2014.11.002 Text en © 2015 Xi'an Jiaotong University. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Original Article
Rambabu, Vinayagam
Suba, Subramaniyan
Vijayakumar, Suburamaniyan
Antimicrobial and antiproliferative prospective of kosinostatin – a secondary metabolite isolated from Streptomyces sp.()
title Antimicrobial and antiproliferative prospective of kosinostatin – a secondary metabolite isolated from Streptomyces sp.()
title_full Antimicrobial and antiproliferative prospective of kosinostatin – a secondary metabolite isolated from Streptomyces sp.()
title_fullStr Antimicrobial and antiproliferative prospective of kosinostatin – a secondary metabolite isolated from Streptomyces sp.()
title_full_unstemmed Antimicrobial and antiproliferative prospective of kosinostatin – a secondary metabolite isolated from Streptomyces sp.()
title_short Antimicrobial and antiproliferative prospective of kosinostatin – a secondary metabolite isolated from Streptomyces sp.()
title_sort antimicrobial and antiproliferative prospective of kosinostatin – a secondary metabolite isolated from streptomyces sp.()
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762245/
https://www.ncbi.nlm.nih.gov/pubmed/29403952
http://dx.doi.org/10.1016/j.jpha.2014.11.002
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