In vitro–in vivo studies of the quantitative effect of calcium, multivitamins and milk on single dose ciprofloxacin bioavailability()

Ciprofloxacin, commonly used in India as an anti-microbial for prolonged use in chronic and non-specific indications, may affect the bioavailability of the drug. The drug prescribed is commonly taken with multivitamins, calcium and milk. A simple and reliable analytical methodology obtaining a corre...

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Autores principales: Dey, Baishakhi, Katakam, Prakash, Assaleh, Fathi H., Chandu, Babu Rao, Adiki, Shanta Kumari, Mitra, Analava
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762247/
https://www.ncbi.nlm.nih.gov/pubmed/29403954
http://dx.doi.org/10.1016/j.jpha.2015.02.003
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author Dey, Baishakhi
Katakam, Prakash
Assaleh, Fathi H.
Chandu, Babu Rao
Adiki, Shanta Kumari
Mitra, Analava
author_facet Dey, Baishakhi
Katakam, Prakash
Assaleh, Fathi H.
Chandu, Babu Rao
Adiki, Shanta Kumari
Mitra, Analava
author_sort Dey, Baishakhi
collection PubMed
description Ciprofloxacin, commonly used in India as an anti-microbial for prolonged use in chronic and non-specific indications, may affect the bioavailability of the drug. The drug prescribed is commonly taken with multivitamins, calcium and milk. A simple and reliable analytical methodology obtaining a correlation with in vivo urinary excretion studies using UV and HPLC and in vitro dissolution studies (IVIVC) has shown a significant increase in elimination rate of ciprofloxacin co-administered with multivitamins, calcium and milk. Appreciable IVIVC results proved that dissolution studies could serve as an alternative to in vivo bioavailability and also support bio-waivers.
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spelling pubmed-57622472018-02-05 In vitro–in vivo studies of the quantitative effect of calcium, multivitamins and milk on single dose ciprofloxacin bioavailability() Dey, Baishakhi Katakam, Prakash Assaleh, Fathi H. Chandu, Babu Rao Adiki, Shanta Kumari Mitra, Analava J Pharm Anal Original Article Ciprofloxacin, commonly used in India as an anti-microbial for prolonged use in chronic and non-specific indications, may affect the bioavailability of the drug. The drug prescribed is commonly taken with multivitamins, calcium and milk. A simple and reliable analytical methodology obtaining a correlation with in vivo urinary excretion studies using UV and HPLC and in vitro dissolution studies (IVIVC) has shown a significant increase in elimination rate of ciprofloxacin co-administered with multivitamins, calcium and milk. Appreciable IVIVC results proved that dissolution studies could serve as an alternative to in vivo bioavailability and also support bio-waivers. Xi'an Jiaotong University 2015-12 2015-03-10 /pmc/articles/PMC5762247/ /pubmed/29403954 http://dx.doi.org/10.1016/j.jpha.2015.02.003 Text en © 2015 Xi'an Jiaotong University http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Dey, Baishakhi
Katakam, Prakash
Assaleh, Fathi H.
Chandu, Babu Rao
Adiki, Shanta Kumari
Mitra, Analava
In vitro–in vivo studies of the quantitative effect of calcium, multivitamins and milk on single dose ciprofloxacin bioavailability()
title In vitro–in vivo studies of the quantitative effect of calcium, multivitamins and milk on single dose ciprofloxacin bioavailability()
title_full In vitro–in vivo studies of the quantitative effect of calcium, multivitamins and milk on single dose ciprofloxacin bioavailability()
title_fullStr In vitro–in vivo studies of the quantitative effect of calcium, multivitamins and milk on single dose ciprofloxacin bioavailability()
title_full_unstemmed In vitro–in vivo studies of the quantitative effect of calcium, multivitamins and milk on single dose ciprofloxacin bioavailability()
title_short In vitro–in vivo studies of the quantitative effect of calcium, multivitamins and milk on single dose ciprofloxacin bioavailability()
title_sort in vitro–in vivo studies of the quantitative effect of calcium, multivitamins and milk on single dose ciprofloxacin bioavailability()
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762247/
https://www.ncbi.nlm.nih.gov/pubmed/29403954
http://dx.doi.org/10.1016/j.jpha.2015.02.003
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