Cargando…

Mitochondrial ROS activates ERK/autophagy pathway as a protected mechanism against deoxypodophyllotoxin-induced apoptosis

Deoxypodophyllotoxin (DPT) is a naturally occurring flavolignan isolated from Anthriscus sylvestris. Recently, it has been reported that DPT inhibits tubulin polymerization and induces G2/M cell cycle arrest followed by apoptosis through multiple cellular processes. Despite these findings, details r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Sang-Hun, Kim, Kwang-Youn, Park, Sul-Gi, Yu, Sun-Nyoung, Kim, Young-Wook, Nam, Hyo-Won, An, Hyun-Hee, Kim, Young-Woo, Ahn, Soon-Cheol
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762344/ https://www.ncbi.nlm.nih.gov/pubmed/29340076 http://dx.doi.org/10.18632/oncotarget.22875

Ejemplares similares

Inhibition of Autophagy Promotes Salinomycin-Induced Apoptosis via Reactive Oxygen Species-Mediated PI3K/AKT/mTOR and ERK/p38 MAPK-Dependent Signaling in Human Prostate Cancer Cells
por: Kim, Kwang-Youn, et al.
Publicado: (2017)

Silibinin induces mitochondrial NOX4-mediated endoplasmic reticulum stress response and its subsequent apoptosis
por: Kim, Sang-Hun, et al.
Publicado: (2016)

Deoxypodophyllotoxin Induces a Th1 Response and Enhances the Antitumor Efficacy of a Dendritic Cell-based Vaccine
por: Lee, Jun Sik, et al.
Publicado: (2011)

Cearoin Induces Autophagy, ERK Activation and Apoptosis via ROS Generation in SH-SY5Y Neuroblastoma Cells
por: Bastola, Tonking, et al.
Publicado: (2017)

Deoxypodophyllotoxin Exerts Anti-Cancer Effects on Colorectal Cancer Cells Through Induction of Apoptosis and Suppression of Tumorigenesis
por: Gamage, Chathurika D. B., et al.
Publicado: (2019)

Deoxypodophyllotoxin Induces ROS-Mediated Apoptosis by Modulating the PI3K/AKT and p38 MAPK-Dependent Signaling in Oral Squamous Cell Carcinoma
por: Seo, Ji-Hye, et al.
Publicado: (2022)

Inhibition of Autophagy Promotes Hemistepsin A-Induced Apoptosis via Reactive Oxygen Species-Mediated AMPK-Dependent Signaling in Human Prostate Cancer Cells
por: Kim, Kwang-Youn, et al.
Publicado: (2021)

Deoxypodophyllotoxin Inhibits Cell Growth and Induces Apoptosis by Blocking EGFR and MET in Gefitinib-Resistant Non-Small Cell Lung Cancer
por: Kim, Han Sol, et al.
Publicado: (2021)

Mechanistic analysis of carbon–carbon bond formation by deoxypodophyllotoxin synthase
por: Tang, Haoyu, et al.
Publicado: (2021)

Chrysin Induces Apoptosis via the MAPK Pathway and Regulates ERK/mTOR-Mediated Autophagy in MC-3 Cells
por: Jung, Gi-Hwan, et al.
Publicado: (2022)

Salinomycin enhances doxorubicin-induced cytotoxicity in multidrug resistant MCF-7/MDR human breast cancer cells via decreased efflux of doxorubicin
por: KIM, KWANG-YOUN, et al.
Publicado: (2015)

C-Peptide Activates AMPKα and Prevents ROS-Mediated Mitochondrial Fission and Endothelial Apoptosis in Diabetes
por: Bhatt, Mahendra Prasad, et al.
Publicado: (2013)

Spermidine Attenuates Oxidative Stress-Induced Apoptosis via Blocking Ca(2+) Overload in Retinal Pigment Epithelial Cells Independently of ROS
por: Kim, Da Hye, et al.
Publicado: (2021)

Inhibitory Effect of Biotransformed-Fucoidan on the Differentiation of Osteoclasts Induced by Receptor for Activation of Nuclear Factor-κB Ligand
por: Park, Bobae, et al.
Publicado: (2022)

Corrigendum to: Deoxypodophyllotoxin Induces ROSMediated Apoptosis by Modulating the PI3K/AKT and p38 MAPK-Dependent Signaling in Oral Squamous Cell Carcinoma
por: Seo, Ji-Hye, et al.
Publicado: (2022)

Simultaneous Induction of Non-Canonical Autophagy and Apoptosis in Cancer Cells by ROS-Dependent ERK and JNK Activation
por: Wong, Chew Hooi, et al.
Publicado: (2010)

Synthesis of (−)−deoxypodophyllotoxin and (−)−epipodophyllotoxin via a multi-enzyme cascade in E. coli
por: Decembrino, Davide, et al.
Publicado: (2021)

Cinnamaldehyde and Hyperthermia Co-Treatment Synergistically Induces ROS-Mediated Apoptosis in ACHN Renal Cell Carcinoma Cells
por: Ahn, Chae Ryeong, et al.
Publicado: (2020)

Induction of Apoptosis by Coptisine in Hep3B Hepatocellular Carcinoma Cells through Activation of the ROS-Mediated JNK Signaling Pathway
por: Kim, So Young, et al.
Publicado: (2020)

Quercetin Induces Mitochondrial Mediated Apoptosis and Protective Autophagy in Human Glioblastoma U373MG Cells
por: Kim, Hyeonji, et al.
Publicado: (2013)

Dendropanoxide Induces Autophagy through ERK1/2 Activation in MG-63 Human Osteosarcoma Cells and Autophagy Inhibition Enhances Dendropanoxide-Induced Apoptosis
por: Lee, Ji-Won, et al.
Publicado: (2013)

Deoxypodophyllotoxin Induces G2/M Cell Cycle Arrest and Apoptosis in SGC-7901 Cells and Inhibits Tumor Growth in Vivo
por: Wang, Yu-Rong, et al.
Publicado: (2015)

Honokiol ameliorates oxidative stress-induced DNA damage and apoptosis of c2c12 myoblasts by ROS generation and mitochondrial pathway
por: Park, Cheol, et al.
Publicado: (2019)

Anti-Proliferative and Pro-Apoptotic Effects of Licochalcone A through ROS-Mediated Cell Cycle Arrest and Apoptosis in Human Bladder Cancer Cells
por: Hong, Su Hyun, et al.
Publicado: (2019)

Correction: Simultaneous Induction of Non-Canonical Autophagy and Apoptosis in Cancer Cells by ROS-Dependent ERK and JNK Activation
por: Wong, Chew Hooi, et al.
Publicado: (2016)

Euphorbiasteroid Induces Apoptosis as Well as Autophagy through Modulating SHP-1/STAT3 Pathway in Hepatocellular Carcinoma Cells
por: Kim, Na Young, et al.
Publicado: (2023)

ROS and ERK1/2-mediated caspase-9 activation increases XAF1 expression in dexamethasone-induced apoptosis of EBV-transformed B cells
por: PARK, GA BIN, et al.
Publicado: (2013)

Calcimimetic restores diabetic peripheral neuropathy by ameliorating apoptosis and improving autophagy
por: Chung, You Chul, et al.
Publicado: (2018)

Pyrimethamine Modulates Interplay between Apoptosis and Autophagy in Chronic Myelogenous Leukemia Cells
por: Jung, Young Yun, et al.
Publicado: (2021)

Enhancement of Quercetin-Induced Apoptosis by Cotreatment with Autophagy Inhibitor Is Associated with Augmentation of BAK-Dependent Mitochondrial Pathway in Jurkat T Cells
por: Ha, Eun Ji, et al.
Publicado: (2019)

Phloroglucinol Attenuates DNA Damage and Apoptosis Induced by Oxidative Stress in Human Retinal Pigment Epithelium ARPE-19 Cells by Blocking the Production of Mitochondrial ROS
por: Park, Cheol, et al.
Publicado: (2022)

Induction of Apoptosis by Isoalantolactone in Human Hepatocellular Carcinoma Hep3B Cells through Activation of the ROS-Dependent JNK Signaling Pathway
por: Kim, Min Yeong, et al.
Publicado: (2021)

Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy
por: Sung, Bokyung, et al.
Publicado: (2016)

Ponciri Fructus Immatarus Sensitizes the Apoptotic Effect of Hyperthermia Treatment in AGS Gastric Cancer Cells through ROS-Dependent HSP Suppression
por: Ahn, Chae Ryeong, et al.
Publicado: (2023)

Does low lead exposure affect blood pressure and hypertension?
por: Kim, Min Gi, et al.
Publicado: (2019)

Ethanol extract of Chrysanthemum zawadskii Herbich induces autophagy and apoptosis in mouse colon cancer cells through the regulation of reactive oxygen species
por: Kim, Kwang-Youn, et al.
Publicado: (2019)

Cinacalcet-mediated activation of the CaMKKβ-LKB1-AMPK pathway attenuates diabetic nephropathy in db/db mice by modulation of apoptosis and autophagy
por: Lim, Ji Hee, et al.
Publicado: (2018)

Piperlongumine induces apoptosis via the MAPK pathway and ERK-mediated autophagy in human melanoma cells
por: Jeon, Su-Ji, et al.
Publicado: (2023)

Ethanol Extract of Hizikia fusiforme Induces Apoptosis in B16F10 Mouse Melanoma Cells through ROS-Dependent Inhibition of the PI3K/Akt Signaling Pathway
por: Park, Cheol, et al.
Publicado: (2020)

Polyphenols from Korean prostrate spurge Euphorbia supina induce apoptosis through the Fas-associated extrinsic pathway and activation of ERK in human leukemic U937 cells
por: HAN, MIN-HO, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_l5vtl2o371um3dc0v6qe7c7nu6