LRP6 targeting suppresses gastric tumorigenesis via P14(ARF)–Mdm2–P53-dependent cellular senescence

NLRP6, a member of the Nod-like receptor family, protects against chemically induced intestinal injury and colitis-associated colon cancer. However, the cellular mechanisms involved in this NLRP6-mediated protection remain unclear. Here, we show that NLRP6 was down-regulated in approximately 75% of...

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Detalles Bibliográficos
Autores principales: Wang, Haibin, Xu, Guoxing, Huang, Zhengjie, Li, Weizheng, Cai, Huali, Zhang, Yunda, Xiong, Disheng, Liu, Gang, Wang, Shengjie, Xue, Zengfu, Luo, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762345/
https://www.ncbi.nlm.nih.gov/pubmed/29340077
http://dx.doi.org/10.18632/oncotarget.22876

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