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High glucose enhances the metastatic potential of tongue squamous cell carcinoma via the PKM2 pathway
Previous evidence has indicated an increased cancer risk in individuals with diabetes mellitus (DM). The aim of this study was to investigate the relationship between DM (high glucose) and tongue squamous cell carcinoma (TSCC) and how high glucose mediated the metastatic potential of TSCC. The relat...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762358/ https://www.ncbi.nlm.nih.gov/pubmed/29340090 http://dx.doi.org/10.18632/oncotarget.22907 |
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author | Wang, Wei He, Qianting Yan, Wangxiang Sun, Jingjing Chen, Zujian Liu, Zhonghua Lu, Zhiyuan Hou, Jinsong Shao, Yisen Zhou, Xiaofeng Wang, Anxun |
author_facet | Wang, Wei He, Qianting Yan, Wangxiang Sun, Jingjing Chen, Zujian Liu, Zhonghua Lu, Zhiyuan Hou, Jinsong Shao, Yisen Zhou, Xiaofeng Wang, Anxun |
author_sort | Wang, Wei |
collection | PubMed |
description | Previous evidence has indicated an increased cancer risk in individuals with diabetes mellitus (DM). The aim of this study was to investigate the relationship between DM (high glucose) and tongue squamous cell carcinoma (TSCC) and how high glucose mediated the metastatic potential of TSCC. The relationship between DM and TSCC was assessed in a retrospective study. The role and its mechanism of high glucose on the proliferation, metastatic potential of TSCC were investigated in vitro and in vivo. The prevalence rate of DM in patients with TSCC was 12.84%, which was significantly higher than that (9.7%) in the general population in China. Although no significant difference was observed in the overall survival (OS) rate, TSCC patients with DM have a 1.38-fold increase in relative risk affecting 5-year OS compared to patients without DM. High glucose enhanced the TSCC cell proliferation, migration, invasion and upregulated PKM2 (pyruvate kinase M2) expression. Whereas, these effect was abolished after knockdown of PKM2 in TSCC cells. High glucose promoted tumour growth and lung metastasis of TSCC in a DM animal model. Our results confirm DM as a risk factor for the development of TSCC. High glucose enhances the metastatic potential of TSCC through stimulation of the PKM2 pathway. |
format | Online Article Text |
id | pubmed-5762358 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-57623582018-01-16 High glucose enhances the metastatic potential of tongue squamous cell carcinoma via the PKM2 pathway Wang, Wei He, Qianting Yan, Wangxiang Sun, Jingjing Chen, Zujian Liu, Zhonghua Lu, Zhiyuan Hou, Jinsong Shao, Yisen Zhou, Xiaofeng Wang, Anxun Oncotarget Research Paper Previous evidence has indicated an increased cancer risk in individuals with diabetes mellitus (DM). The aim of this study was to investigate the relationship between DM (high glucose) and tongue squamous cell carcinoma (TSCC) and how high glucose mediated the metastatic potential of TSCC. The relationship between DM and TSCC was assessed in a retrospective study. The role and its mechanism of high glucose on the proliferation, metastatic potential of TSCC were investigated in vitro and in vivo. The prevalence rate of DM in patients with TSCC was 12.84%, which was significantly higher than that (9.7%) in the general population in China. Although no significant difference was observed in the overall survival (OS) rate, TSCC patients with DM have a 1.38-fold increase in relative risk affecting 5-year OS compared to patients without DM. High glucose enhanced the TSCC cell proliferation, migration, invasion and upregulated PKM2 (pyruvate kinase M2) expression. Whereas, these effect was abolished after knockdown of PKM2 in TSCC cells. High glucose promoted tumour growth and lung metastasis of TSCC in a DM animal model. Our results confirm DM as a risk factor for the development of TSCC. High glucose enhances the metastatic potential of TSCC through stimulation of the PKM2 pathway. Impact Journals LLC 2017-12-04 /pmc/articles/PMC5762358/ /pubmed/29340090 http://dx.doi.org/10.18632/oncotarget.22907 Text en Copyright: © 2017 Wang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Wang, Wei He, Qianting Yan, Wangxiang Sun, Jingjing Chen, Zujian Liu, Zhonghua Lu, Zhiyuan Hou, Jinsong Shao, Yisen Zhou, Xiaofeng Wang, Anxun High glucose enhances the metastatic potential of tongue squamous cell carcinoma via the PKM2 pathway |
title | High glucose enhances the metastatic potential of tongue squamous cell carcinoma via the PKM2 pathway |
title_full | High glucose enhances the metastatic potential of tongue squamous cell carcinoma via the PKM2 pathway |
title_fullStr | High glucose enhances the metastatic potential of tongue squamous cell carcinoma via the PKM2 pathway |
title_full_unstemmed | High glucose enhances the metastatic potential of tongue squamous cell carcinoma via the PKM2 pathway |
title_short | High glucose enhances the metastatic potential of tongue squamous cell carcinoma via the PKM2 pathway |
title_sort | high glucose enhances the metastatic potential of tongue squamous cell carcinoma via the pkm2 pathway |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762358/ https://www.ncbi.nlm.nih.gov/pubmed/29340090 http://dx.doi.org/10.18632/oncotarget.22907 |
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