Application of a UPLC–MS/MS method to the protein binding study of TM-2 in rat, human and beagle dog plasma()

TM-2 known as a potential antitumor drug is a novel semi-synthetic taxane derivative. As drug–protein interactions contribute to insights into pharmacokinetic and pharmacodynamic properties, we elucidated the binding of TM-2 to plasma protein. In this study, a simple, rapid and reliable method was d...

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Detalles Bibliográficos
Autores principales: Liu, Hui, Wu, Pan-Pan, Yang, Ming-Jing, Men, Lei, Lin, Hong-Li, Zhao, Yun-Li, Tang, Xing, Yu, Zhi-Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762439/
https://www.ncbi.nlm.nih.gov/pubmed/29403960
http://dx.doi.org/10.1016/j.jpha.2015.08.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762439/
https://www.ncbi.nlm.nih.gov/pubmed/29403960
http://dx.doi.org/10.1016/j.jpha.2015.08.001

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