Lysosome-targeting agents in cancer therapy

Despite considerable efforts from multiple laboratories worldwide, highly specific inhibitors of autophagy for clinical use are not yet available. Lysosomal inhibitors are being employed instead, in spite of multiple limitations that are summarized herein.

Detalles Bibliográficos
Autores principales: Kroemer, Guido, Galluzzi, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Perspective: Autophagy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762500/
https://www.ncbi.nlm.nih.gov/pubmed/29348815
http://dx.doi.org/10.18632/oncotarget.21451
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author Kroemer, Guido
Galluzzi, Lorenzo
author_facet Kroemer, Guido
Galluzzi, Lorenzo
author_sort Kroemer, Guido
collection PubMed
description Despite considerable efforts from multiple laboratories worldwide, highly specific inhibitors of autophagy for clinical use are not yet available. Lysosomal inhibitors are being employed instead, in spite of multiple limitations that are summarized herein.
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spelling pubmed-57625002018-01-18 Lysosome-targeting agents in cancer therapy Kroemer, Guido Galluzzi, Lorenzo Oncotarget Research Perspective: Autophagy Despite considerable efforts from multiple laboratories worldwide, highly specific inhibitors of autophagy for clinical use are not yet available. Lysosomal inhibitors are being employed instead, in spite of multiple limitations that are summarized herein. Impact Journals LLC 2017-10-03 /pmc/articles/PMC5762500/ /pubmed/29348815 http://dx.doi.org/10.18632/oncotarget.21451 Text en Copyright: © 2017 Kroemer and Galluzzi http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Perspective: Autophagy
Kroemer, Guido
Galluzzi, Lorenzo
Lysosome-targeting agents in cancer therapy
title Lysosome-targeting agents in cancer therapy
title_full Lysosome-targeting agents in cancer therapy
title_fullStr Lysosome-targeting agents in cancer therapy
title_full_unstemmed Lysosome-targeting agents in cancer therapy
title_short Lysosome-targeting agents in cancer therapy
title_sort lysosome-targeting agents in cancer therapy
topic Research Perspective: Autophagy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762500/
https://www.ncbi.nlm.nih.gov/pubmed/29348815
http://dx.doi.org/10.18632/oncotarget.21451
work_keys_str_mv AT kroemerguido lysosometargetingagentsincancertherapy
AT galluzzilorenzo lysosometargetingagentsincancertherapy

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