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A Mitochondrial-targeted purine-based HSP90 antagonist for leukemia therapy

Reprogramming of mitochondrial functions sustains tumor growth and may provide therapeutic opportunities. Here, we targeted the protein folding environment in mitochondria by coupling a purine-based inhibitor of the molecular chaperone Heat Shock Protein-90 (Hsp90), PU-H71 to the mitochondrial-targe...

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Detalles Bibliográficos
Autores principales:	Bryant, Kelly G., Chae, Young Chan, Martinez, Rogelio L., Gordon, John C., Elokely, Khaled M., Kossenkov, Andrew V., Grant, Steven, Childers, Wayne E., Abou-Gharbia, Magid, Altieri, Dario C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Priority Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762502/ https://www.ncbi.nlm.nih.gov/pubmed/29348817 http://dx.doi.org/10.18632/oncotarget.23097

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