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A novel anti-CD146 antibody specifically targets cancer cells by internalizing the molecule

CD146 is an adhesion molecule present on many tumors (melanoma, kidney, pancreas, breast, ...). In addition, it has been shown to be expressed on vascular endothelial and smooth muscle cells. Generating an antibody able to specifically recognize CD146 in cancer cells (designated as tumor CD146), but...

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Detalles Bibliográficos
Autores principales: Nollet, Marie, Stalin, Jimmy, Moyon, Anaïs, Traboulsi, Waël, Essaadi, Amel, Robert, Stéphane, Malissen, Nausicaa, Bachelier, Richard, Daniel, Laurent, Foucault-Bertaud, Alexandrine, Gaudy-Marqueste, Caroline, Lacroix, Romaric, Leroyer, Aurélie S, Guillet, Benjamin, Bardin, Nathalie, Dignat-George, Françoise, Blot-Chabaud, Marcel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762510/
https://www.ncbi.nlm.nih.gov/pubmed/29348825
http://dx.doi.org/10.18632/oncotarget.22736