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Inactivation/deficiency of DHODH induces cell cycle arrest and programed cell death in melanoma

Malignant melanoma (MM) is one of the most malignant tumors and has a very poor prognosis. However, there are no effective drugs to treat this disease. As a kind of iron flavin dependent enzyme, dihydroorotate dehydrogenase (DHODH, EC 1.3.3.1) is the fourth and a key enzyme in the de novo biosynthes...

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Detalles Bibliográficos
Autores principales:	Liu, Lichao, Dong, Zhen, Lei, Qian, Yang, Jie, Hu, Huanrong, Li, Qian, Ji, Yacong, Guo, Leiyang, Zhang, Yanli, Liu, Yaling, Cui, Hongjuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762515/ https://www.ncbi.nlm.nih.gov/pubmed/29348830 http://dx.doi.org/10.18632/oncotarget.19379

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