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Single nucleotide polymorphisms in ZNF208 are associated with increased risk for HBV in Chinese people
Single nucleotide polymorphisms (SNPs) in ZNF208 may be associated with susceptibility to Hepatitis B virus (HBV). In the current study, we analyzed the association between ZNF208 SNPs and risk of HBV in 242 HBV patients and 300 healthy subjects from the Xi'an area of Chinese Han Population. Of...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762523/ https://www.ncbi.nlm.nih.gov/pubmed/29348838 http://dx.doi.org/10.18632/oncotarget.19669 |
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author | Li, Hengxin Chen, Jun Zhang, RuiZhi Xu, Ran Zhang, Zhe Ren, Le Yang, Qi Tian, Yumei Li, Daxu |
author_facet | Li, Hengxin Chen, Jun Zhang, RuiZhi Xu, Ran Zhang, Zhe Ren, Le Yang, Qi Tian, Yumei Li, Daxu |
author_sort | Li, Hengxin |
collection | PubMed |
description | Single nucleotide polymorphisms (SNPs) in ZNF208 may be associated with susceptibility to Hepatitis B virus (HBV). In the current study, we analyzed the association between ZNF208 SNPs and risk of HBV in 242 HBV patients and 300 healthy subjects from the Xi'an area of Chinese Han Population. Of the five SNPs examined, rs2188971 (OR: 1.36, 95% CI: 1.04-1.76, P = 0.022), rs8103163 (OR: 1.40, 95% CI: 1.08-1.82, P = 0.010) and rs7248488 (OR: 1.38, 95% CI: 1.07-1.79, P = 0.014) were correlated with HBV susceptibility based on Chi-square tests. After the P-values were adjusted by Bonferroni correction, there only rs8103163 (P = 0.050) was slightly with increased HBV risk. Additionally, haplotype A(rs2188972)T(rs2188971)A(rs8103163)A(rs7248488) (OR = 1.42; 95% C I, 1.10-1.85; P = 0.008) was found to increase susceptibility of suffering from HBV. These findings suggest that ZNF208 polymorphisms may contribute to the development of HBV. |
format | Online Article Text |
id | pubmed-5762523 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-57625232018-01-18 Single nucleotide polymorphisms in ZNF208 are associated with increased risk for HBV in Chinese people Li, Hengxin Chen, Jun Zhang, RuiZhi Xu, Ran Zhang, Zhe Ren, Le Yang, Qi Tian, Yumei Li, Daxu Oncotarget Research Paper Single nucleotide polymorphisms (SNPs) in ZNF208 may be associated with susceptibility to Hepatitis B virus (HBV). In the current study, we analyzed the association between ZNF208 SNPs and risk of HBV in 242 HBV patients and 300 healthy subjects from the Xi'an area of Chinese Han Population. Of the five SNPs examined, rs2188971 (OR: 1.36, 95% CI: 1.04-1.76, P = 0.022), rs8103163 (OR: 1.40, 95% CI: 1.08-1.82, P = 0.010) and rs7248488 (OR: 1.38, 95% CI: 1.07-1.79, P = 0.014) were correlated with HBV susceptibility based on Chi-square tests. After the P-values were adjusted by Bonferroni correction, there only rs8103163 (P = 0.050) was slightly with increased HBV risk. Additionally, haplotype A(rs2188972)T(rs2188971)A(rs8103163)A(rs7248488) (OR = 1.42; 95% C I, 1.10-1.85; P = 0.008) was found to increase susceptibility of suffering from HBV. These findings suggest that ZNF208 polymorphisms may contribute to the development of HBV. Impact Journals LLC 2017-07-28 /pmc/articles/PMC5762523/ /pubmed/29348838 http://dx.doi.org/10.18632/oncotarget.19669 Text en Copyright: © 2017 Li et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Li, Hengxin Chen, Jun Zhang, RuiZhi Xu, Ran Zhang, Zhe Ren, Le Yang, Qi Tian, Yumei Li, Daxu Single nucleotide polymorphisms in ZNF208 are associated with increased risk for HBV in Chinese people |
title | Single nucleotide polymorphisms in ZNF208 are associated with increased risk for HBV in Chinese people |
title_full | Single nucleotide polymorphisms in ZNF208 are associated with increased risk for HBV in Chinese people |
title_fullStr | Single nucleotide polymorphisms in ZNF208 are associated with increased risk for HBV in Chinese people |
title_full_unstemmed | Single nucleotide polymorphisms in ZNF208 are associated with increased risk for HBV in Chinese people |
title_short | Single nucleotide polymorphisms in ZNF208 are associated with increased risk for HBV in Chinese people |
title_sort | single nucleotide polymorphisms in znf208 are associated with increased risk for hbv in chinese people |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762523/ https://www.ncbi.nlm.nih.gov/pubmed/29348838 http://dx.doi.org/10.18632/oncotarget.19669 |
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