Differences in the expression of long noncoding RNAs at different time points in the PTSD-like syndrome rat hippocampus

The aim of this study was to characterize the expression profiles at different time points in the PTSD-like syndrome rat hippocampus and perform analyses. PTSD rat models were made as reported by Rau, and we collected the hippocampus at different time points. The lncRNAs at different time points wer...

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Detalles Bibliográficos
Autores principales: Liu, Qingzhen, Ji, Qing, Liu, Jian, Zhang, Lidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762524/
https://www.ncbi.nlm.nih.gov/pubmed/29348839
http://dx.doi.org/10.18632/oncotarget.21025
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author Liu, Qingzhen
Ji, Qing
Liu, Jian
Zhang, Lidong
author_facet Liu, Qingzhen
Ji, Qing
Liu, Jian
Zhang, Lidong
author_sort Liu, Qingzhen
collection PubMed
description The aim of this study was to characterize the expression profiles at different time points in the PTSD-like syndrome rat hippocampus and perform analyses. PTSD rat models were made as reported by Rau, and we collected the hippocampus at different time points. The lncRNAs at different time points were compared by microarray and listed. We used quantitative real-time PCR to confirm the lncRNA profiling expression data. Bioinformatics analysis was performed on EU056364_P1. Compare with control, a total of 948 lncRNAs and 2514 mRNAs were found (fold-change > 2.0) among the four time points. Additionally, bioinformatics analysis of EU056364_P1 suggested it might be involved in memory development through the target gene Camk2a.This study revealed different lncRNAs expressed at different time points in PTSD and explored the targets of PTSD.
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spelling pubmed-57625242018-01-18 Differences in the expression of long noncoding RNAs at different time points in the PTSD-like syndrome rat hippocampus Liu, Qingzhen Ji, Qing Liu, Jian Zhang, Lidong Oncotarget Research Paper The aim of this study was to characterize the expression profiles at different time points in the PTSD-like syndrome rat hippocampus and perform analyses. PTSD rat models were made as reported by Rau, and we collected the hippocampus at different time points. The lncRNAs at different time points were compared by microarray and listed. We used quantitative real-time PCR to confirm the lncRNA profiling expression data. Bioinformatics analysis was performed on EU056364_P1. Compare with control, a total of 948 lncRNAs and 2514 mRNAs were found (fold-change > 2.0) among the four time points. Additionally, bioinformatics analysis of EU056364_P1 suggested it might be involved in memory development through the target gene Camk2a.This study revealed different lncRNAs expressed at different time points in PTSD and explored the targets of PTSD. Impact Journals LLC 2017-09-18 /pmc/articles/PMC5762524/ /pubmed/29348839 http://dx.doi.org/10.18632/oncotarget.21025 Text en Copyright: © 2017 Liu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Liu, Qingzhen
Ji, Qing
Liu, Jian
Zhang, Lidong
Differences in the expression of long noncoding RNAs at different time points in the PTSD-like syndrome rat hippocampus
title Differences in the expression of long noncoding RNAs at different time points in the PTSD-like syndrome rat hippocampus
title_full Differences in the expression of long noncoding RNAs at different time points in the PTSD-like syndrome rat hippocampus
title_fullStr Differences in the expression of long noncoding RNAs at different time points in the PTSD-like syndrome rat hippocampus
title_full_unstemmed Differences in the expression of long noncoding RNAs at different time points in the PTSD-like syndrome rat hippocampus
title_short Differences in the expression of long noncoding RNAs at different time points in the PTSD-like syndrome rat hippocampus
title_sort differences in the expression of long noncoding rnas at different time points in the ptsd-like syndrome rat hippocampus
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762524/
https://www.ncbi.nlm.nih.gov/pubmed/29348839
http://dx.doi.org/10.18632/oncotarget.21025
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