Decreased expression of the long non-coding RNA SLC7A11-AS1 predicts poor prognosis and promotes tumor growth in gastric cancer

Many lncRNA and mRNA sense-antisense transcripts have been systematically identified in malignant cells. However, the molecular mechanisms of most lncRNA-mRNA pairs in gastric cancer remain largely unknown. We found the gastric cancer-associated lncRNA SLC7A11-AS1 and coding transcript mRNA SLC7A11...

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Autores principales: Luo, Yajun, Wang, Cheng, Yong, Peng, Ye, Pengcheng, Liu, Zilin, Fu, Zhiming, Lu, Fei, Xiang, Wanping, Tan, Wang, Xiao, Jiangwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762530/
https://www.ncbi.nlm.nih.gov/pubmed/29348845
http://dx.doi.org/10.18632/oncotarget.22486
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author Luo, Yajun
Wang, Cheng
Yong, Peng
Ye, Pengcheng
Liu, Zilin
Fu, Zhiming
Lu, Fei
Xiang, Wanping
Tan, Wang
Xiao, Jiangwei
author_facet Luo, Yajun
Wang, Cheng
Yong, Peng
Ye, Pengcheng
Liu, Zilin
Fu, Zhiming
Lu, Fei
Xiang, Wanping
Tan, Wang
Xiao, Jiangwei
author_sort Luo, Yajun
collection PubMed
description Many lncRNA and mRNA sense-antisense transcripts have been systematically identified in malignant cells. However, the molecular mechanisms of most lncRNA-mRNA pairs in gastric cancer remain largely unknown. We found the gastric cancer-associated lncRNA SLC7A11-AS1 and coding transcript mRNA SLC7A11 in human gastric cancer specimens by microarray. SLC7A11-AS1, antisense to SLC7A11, is significantly down-regulated in gastric cancer and could promote tumor growth in vitro and in vivo. The effects of SLC7A11-AS1 depend on the regulation of SLC7A11 via the ASK1-p38(MAPK)/JNK signaling pathway. These findings suggest that decreased expression of SLC7A11-AS1 contributes to the progression of gastric cancer and may be a novel diagnostic biomarker and effective therapeutic target in gastric cancer patients.
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spelling pubmed-57625302018-01-18 Decreased expression of the long non-coding RNA SLC7A11-AS1 predicts poor prognosis and promotes tumor growth in gastric cancer Luo, Yajun Wang, Cheng Yong, Peng Ye, Pengcheng Liu, Zilin Fu, Zhiming Lu, Fei Xiang, Wanping Tan, Wang Xiao, Jiangwei Oncotarget Research Paper Many lncRNA and mRNA sense-antisense transcripts have been systematically identified in malignant cells. However, the molecular mechanisms of most lncRNA-mRNA pairs in gastric cancer remain largely unknown. We found the gastric cancer-associated lncRNA SLC7A11-AS1 and coding transcript mRNA SLC7A11 in human gastric cancer specimens by microarray. SLC7A11-AS1, antisense to SLC7A11, is significantly down-regulated in gastric cancer and could promote tumor growth in vitro and in vivo. The effects of SLC7A11-AS1 depend on the regulation of SLC7A11 via the ASK1-p38(MAPK)/JNK signaling pathway. These findings suggest that decreased expression of SLC7A11-AS1 contributes to the progression of gastric cancer and may be a novel diagnostic biomarker and effective therapeutic target in gastric cancer patients. Impact Journals LLC 2017-11-07 /pmc/articles/PMC5762530/ /pubmed/29348845 http://dx.doi.org/10.18632/oncotarget.22486 Text en Copyright: © 2017 Luo et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Luo, Yajun
Wang, Cheng
Yong, Peng
Ye, Pengcheng
Liu, Zilin
Fu, Zhiming
Lu, Fei
Xiang, Wanping
Tan, Wang
Xiao, Jiangwei
Decreased expression of the long non-coding RNA SLC7A11-AS1 predicts poor prognosis and promotes tumor growth in gastric cancer
title Decreased expression of the long non-coding RNA SLC7A11-AS1 predicts poor prognosis and promotes tumor growth in gastric cancer
title_full Decreased expression of the long non-coding RNA SLC7A11-AS1 predicts poor prognosis and promotes tumor growth in gastric cancer
title_fullStr Decreased expression of the long non-coding RNA SLC7A11-AS1 predicts poor prognosis and promotes tumor growth in gastric cancer
title_full_unstemmed Decreased expression of the long non-coding RNA SLC7A11-AS1 predicts poor prognosis and promotes tumor growth in gastric cancer
title_short Decreased expression of the long non-coding RNA SLC7A11-AS1 predicts poor prognosis and promotes tumor growth in gastric cancer
title_sort decreased expression of the long non-coding rna slc7a11-as1 predicts poor prognosis and promotes tumor growth in gastric cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762530/
https://www.ncbi.nlm.nih.gov/pubmed/29348845
http://dx.doi.org/10.18632/oncotarget.22486
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