Cargando…

Gene expression profiling reveals U1 snRNA regulates cancer gene expression

U1 small nuclear RNA (U1 snRNA), as one of the most abundant ncRNAs in human cells, plays an important role in splicing of pre-mRNAs. Compared to previous studies which have focused on the primary function of U1 snRNA and the neurodegenerative diseases caused by abnormalities of U1 snRNA, this study...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, Zhi, Sun, Yu, Niu, Xiaoran, Shang, Yingchun, Ruan, Jishou, Chen, Ze, Gao, Shan, Zhang, Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762557/ https://www.ncbi.nlm.nih.gov/pubmed/29348872 http://dx.doi.org/10.18632/oncotarget.22842

Ejemplares similares

U7 snRNA: A tool for gene therapy
por: Gadgil, Ankur, et al.
Publicado: (2021)

RNA-mediated interaction of Cajal bodies and U2 snRNA genes
por: Frey, Mark R., et al.
Publicado: (2001)

Chemical Synthesis of U1 snRNA Derivatives
por: Ohkubo, Akihiro, et al.
Publicado: (2013)

U6 snRNA expression prevents toxicity in TDP-43-knockdown cells
por: Yahara, Masao, et al.
Publicado: (2017)

Regulation of expression of human RNA polymerase II-transcribed snRNA genes
por: Guiro, Joana, et al.
Publicado: (2017)

CAPTURE of the Human U2 snRNA Genes Expands the Repertoire of Associated Factors
por: Guiro, Joana, et al.
Publicado: (2022)

Intronic cleavage and polyadenylation regulates gene expression during DNA damage response through U1 snRNA
por: Devany, Emral, et al.
Publicado: (2016)

Architecture of the U6 snRNP reveals specific recognition of 3′-end processed U6 snRNA
por: Montemayor, Eric J., et al.
Publicado: (2018)

Spliceosomal snRNA Epitranscriptomics
por: Morais, Pedro, et al.
Publicado: (2021)

Developmental Analysis of Spliceosomal snRNA Isoform Expression
por: Lu, Zhipeng, et al.
Publicado: (2014)

LSM1 over-expression in Saccharomyces cerevisiae depletes U6 snRNA levels
por: Luhtala, Natalie, et al.
Publicado: (2009)

Snord94 expression level alters methylation at C(62) in snRNA U6
por: Ogren, Allison, et al.
Publicado: (2019)

Functionally important structural elements of U12 snRNA
por: Sikand, Kavleen, et al.
Publicado: (2011)

Conformational dynamics of stem II of the U2 snRNA
por: Rodgers, Margaret L., et al.
Publicado: (2016)

Requirements for gene silencing mediated by U1 snRNA binding to a target sequence
por: Abad, Xabi, et al.
Publicado: (2008)

U3 snoRNA genes are multi-copy and frequently linked to U5 snRNA genes in Euglena gracilis(§)
por: Charette, J Michael, et al.
Publicado: (2009)

Cajal body surveillance of U snRNA export complex assembly
por: Suzuki, Tatsuya, et al.
Publicado: (2010)

U6 snRNA Pseudogenes: Markers of Retrotransposition Dynamics in Mammals
por: Doucet, Aurélien J., et al.
Publicado: (2015)

Crystal structures of U6 snRNA-specific terminal uridylyltransferase
por: Yamashita, Seisuke, et al.
Publicado: (2017)

U5 snRNA Interactions With Exons Ensure Splicing Precision
por: Artemyeva-Isman, Olga V., et al.
Publicado: (2021)

Development of Engineered-U1 snRNA Therapies: Current Status
por: Gonçalves, Mariana, et al.
Publicado: (2023)

Mechanism of U6 snRNA oligouridylation by human TUT1
por: Yamashita, Seisuke, et al.
Publicado: (2023)

U4 snRNA nucleolar localization requires the NHPX/15.5-kD protein binding site but not Sm protein or U6 snRNA association
por: Gerbi, Susan A., et al.
Publicado: (2003)

A New Class of SINEs with snRNA Gene-Derived Heads
por: Kojima, Kenji K.
Publicado: (2015)

The TOR signaling pathway regulates starvation-induced pseudouridylation of yeast U2 snRNA
por: Wu, Guowei, et al.
Publicado: (2016)

Endogenous U2·U5·U6 snRNA complexes in S. pombe are intron lariat spliceosomes
por: Chen, Weijun, et al.
Publicado: (2014)

Identification of truncated forms of U1 snRNA reveals a novel RNA degradation pathway during snRNP biogenesis
por: Ishikawa, Hideaki, et al.
Publicado: (2014)

Deletions of singular U1 snRNA gene significantly interfere with transcription and 3’-end mRNA formation
por: Wang, Mei, et al.
Publicado: (2023)

Pseudouridine modification in Caenorhabditis elegans spliceosomal snRNAs: unique modifications are found in regions involved in snRNA-snRNA interactions
por: Patton, Jeffrey R, et al.
Publicado: (2005)

PanCancer analysis of somatic mutations in repetitive regions reveals recurrent mutations in snRNA U2
por: Bousquets-Muñoz, Pablo, et al.
Publicado: (2022)

Human U1 snRNA forms a new chromatin-associated snRNP with TAF15
por: Jobert, Laure, et al.
Publicado: (2009)

Structural and mechanistic basis for preferential deadenylation of U6 snRNA by Usb1
por: Nomura, Yuichiro, et al.
Publicado: (2018)

The Myb domain of the largest subunit of SNAPc adopts different architectural configurations on U1 and U6 snRNA gene promoter sequences
por: Kang, Yoon Soon, et al.
Publicado: (2014)

Minor introns are embedded molecular switches regulated by highly unstable U6atac snRNA
por: Younis, Ihab, et al.
Publicado: (2013)

Splicing Mutations Impairing CDKL5 Expression and Activity Can be Efficiently Rescued by U1snRNA-Based Therapy
por: Balestra, Dario, et al.
Publicado: (2019)

Somatic Therapy of a Mouse SMA Model with a U7 snRNA Gene Correcting SMN2 Splicing
por: Odermatt, Philipp, et al.
Publicado: (2016)

Binding Affinity and Cooperativity Control U2B″/snRNA/U2A′ RNP Formation
por: Williams, Sandra G., et al.
Publicado: (2014)

Post-transcriptional modifications modulate conformational dynamics in human U2–U6 snRNA complex
por: Karunatilaka, Krishanthi S., et al.
Publicado: (2014)

Incorporation of 5-fluorouracil into U2 snRNA blocks pseudouridylation and pre-mRNA splicing in vivo
por: Zhao, Xinliang, et al.
Publicado: (2007)

Enhancement of β‐Globin Gene Expression in Thalassemic IVS2‐654 Induced Pluripotent Stem Cell‐Derived Erythroid Cells by Modified U7 snRNA
por: Phanthong, Phetcharat, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_71upsh9mckhpaunf7e4k2aftdt