Loss of NEIL3 DNA glycosylase markedly increases replication associated double strand breaks and enhances sensitivity to ATR inhibitor in glioblastoma cells

DNA endonuclease eight-like glycosylase 3 (NEIL3) is one of the DNA glycosylases that removes oxidized DNA base lesions from single-stranded DNA (ssDNA) and non-B DNA structures. Approximately seven percent of human tumors have an altered NEIL3 gene. However, the role of NEIL3 in replication-associa...

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Detalles Bibliográficos
Autores principales: Klattenhoff, Alex W., Thakur, Megha, Chu, Christopher S., Ray, Debolina, Habib, Samy L., Kidane, Dawit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762564/
https://www.ncbi.nlm.nih.gov/pubmed/29348879
http://dx.doi.org/10.18632/oncotarget.22896

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