Cargando…

FRK inhibits breast cancer cell migration and invasion by suppressing epithelial-mesenchymal transition

The human fyn-related kinase (FRK) is a non-receptor tyrosine kinase known to have tumor suppressor activity in breast cancer cells. However, its mechanism of action has not been fully characterized. We generated FRK-stable MDA-MB-231 breast cancer cell lines and analyzed the effect on cell prolifer...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ogunbolude, Yetunde, Dai, Chenlu, Bagu, Edward T, Goel, Raghuveera Kumar, Miah, Sayem, MacAusland-Berg, Joshua, Ng, Chi Ying, Chibbar, Rajni, Napper, Scott, Raptis, Leda, Vizeacoumar, Frederick, Vizeacoumar, Franco, Bonham, Keith, Lukong, Kiven Erique
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762571/ https://www.ncbi.nlm.nih.gov/pubmed/29348886 http://dx.doi.org/10.18632/oncotarget.22958

Ejemplares similares

Estrogen receptor signaling regulates the expression of the breast tumor kinase in breast cancer cells
por: Miah, Sayem, et al.
Publicado: (2019)

Repression of Fyn-related kinase in breast cancer cells is associated with promoter site-specific CpG methylation
por: Bagu, Edward T., et al.
Publicado: (2017)

Global phosphoproteomic analysis identifies SRMS-regulated secondary signaling intermediates
por: Goel, Raghuveera Kumar, et al.
Publicado: (2018)

BRK Targets Dok1 for Ubiquitin-Mediated Proteasomal Degradation to Promote Cell Proliferation and Migration
por: Miah, Sayem, et al.
Publicado: (2014)

BRK phosphorylates SMAD4 for proteasomal degradation and inhibits tumor suppressor FRK to control SNAIL, SLUG, and metastatic potential
por: Miah, S., et al.
Publicado: (2019)

Seeking a better understanding of the non-receptor tyrosine kinase, SRMS
por: Goel, Raghuveera Kumar, et al.
Publicado: (2023)

A Low-Cost Digital Microscope with Real-Time Fluorescent Imaging Capability
por: Hasan, Md. Mehedi, et al.
Publicado: (2016)

Understanding breast cancer – The long and winding road
por: Lukong, Kiven Erique
Publicado: (2017)

Breast Cancer Stem-Like Cells in Drug Resistance: A Review of Mechanisms and Novel Therapeutic Strategies to Overcome Drug Resistance
por: Saha, Taniya, et al.
Publicado: (2022)

Triple negative breast cancer: approved treatment options and their mechanisms of action
por: Mandapati, Aditya, et al.
Publicado: (2022)

Humanized yeast genetic interaction mapping predicts synthetic lethal interactions of FBXW7 in breast cancer
por: Kirzinger, Morgan W. B., et al.
Publicado: (2019)

Biochemical characterization of INTS3 and C9ORF80, two subunits of hNABP1/2 heterotrimeric complex in nucleic acid binding
por: Vidhyasagar, Venkatasubramanian, et al.
Publicado: (2018)

Molecular characterization of breast cancer cell lines through multiple omic approaches
por: Smith, Shari E., et al.
Publicado: (2017)

APOBEC1 cytosine deaminase activity on single-stranded DNA is suppressed by replication protein A
por: Wong, Lai, et al.
Publicado: (2020)

Successful conversion from butorphanol nasal spray to buprenorphine/naloxone using a low-dose regimen to assist with opioid tapering in the setting of chronic pain and migraine management in an older adult patient: A case report
por: MacAusland-Berg, Joshua, et al.
Publicado: (2022)

Expression-based analyses indicate a central role for hypoxia in driving tumor plasticity through microenvironment remodeling and chromosomal instability
por: Jing, Anqi, et al.
Publicado: (2018)

Protein Tyrosine Kinases: Their Roles and Their Targeting in Leukemia
por: K. Bhanumathy, Kalpana, et al.
Publicado: (2021)

The CINs of Polo-Like Kinase 1 in Cancer
por: Cunningham, Chelsea E., et al.
Publicado: (2020)

Emerging data supporting stromal cell therapeutic potential in cancer: reprogramming stromal cells of the tumor microenvironment for anti-cancer effects
por: Nwabo Kamdje, Armel Hervé, et al.
Publicado: (2020)

Tumor Microenvironment Uses a Reversible Reprogramming of Mesenchymal Stromal Cells to Mediate Pro-tumorigenic Effects
por: Nwabo Kamdje, Armel H., et al.
Publicado: (2020)

The EphB6 receptor is overexpressed in pediatric T cell acute lymphoblastic leukemia and increases its sensitivity to doxorubicin treatment
por: El Zawily, Amr, et al.
Publicado: (2017)

Leukaemic cells expressing ETV6::FRK are sensitive to dasatinib in vivo
por: Mayumi, Azusa, et al.
Publicado: (2023)

Mining the plasma-proteome associated genes in patients with gastro-esophageal cancers for biomarker discovery
por: Vizeacoumar, Frederick S., et al.
Publicado: (2021)

Synthetic lethal interactions of DEAD/H-box helicases as targets for cancer therapy
por: Arna, Ananna Bhadra, et al.
Publicado: (2023)

A new insight into the evolution and functional divergence of FRK genes in Pyrus bretschneideri
por: Cao, Yunpeng, et al.
Publicado: (2018)

Homoharringtonine demonstrates a cytotoxic effect against triple-negative breast cancer cell lines and acts synergistically with paclitaxel
por: Plett, Riley, et al.
Publicado: (2022)

Targetable fusions of the FRK tyrosine kinase in ALK-negative anaplastic large cell lymphoma
por: Hu, G, et al.
Publicado: (2017)

TRIM44 promotes cell proliferation and migration by inhibiting FRK in renal cell carcinoma
por: Yamada, Yuta, et al.
Publicado: (2020)

MdFRK2-mediated sugar metabolism accelerates cellulose accumulation in apple and poplar
por: Su, Jing, et al.
Publicado: (2021)

Developmental pathways associated with cancer metastasis: Notch, Wnt, and Hedgehog
por: Nwabo Kamdje, Armel Herve, et al.
Publicado: (2017)

Mesenchymal stromal cells’ role in tumor microenvironment: involvement of signaling pathways
por: Nwabo Kamdje, Armel Herve, et al.
Publicado: (2017)

PhenoM: a database of morphological phenotypes caused by mutation of essential genes in Saccharomyces cerevisiae
por: Jin, Ke, et al.
Publicado: (2012)

Enhancing the throughput and multiplexing capabilities of next generation sequencing for efficient implementation of pooled shRNA and CRISPR screens
por: Islam, Md. Fahmid, et al.
Publicado: (2017)

Simulated Microgravity Reduces Focal Adhesions and Alters Cytoskeleton and Nuclear Positioning Leading to Enhanced Apoptosis via Suppressing FAK/RhoA-Mediated mTORC1/NF-κB and ERK1/2 Pathways
por: Zhao, Tuo, et al.
Publicado: (2018)

Molecular characterization of an MLL1 fusion and its role in chromosomal instability
por: Parameswaran, Sreejit, et al.
Publicado: (2018)

FRK inhibits glioblastoma progression via phosphorylating YAP and inducing its ubiquitylation and degradation by Siah1
por: Wang, Yan, et al.
Publicado: (2022)

miR-19 promotes the proliferation of clear cell renal cell carcinoma by targeting the FRK–PTEN axis
por: Jing, Zhi-Fei, et al.
Publicado: (2019)

The Solanum chacoense Fertilization-Related Kinase 3 (ScFRK3) is involved in male and female gametophyte development
por: Daigle, Caroline, et al.
Publicado: (2019)

Sympathetic signaling facilitates progression of neuroendocrine prostate cancer
por: Dwivedi, Shubham, et al.
Publicado: (2021)

A Drug Repurposing Screen Identifies Fludarabine Phosphate as a Potential Therapeutic Agent for N-MYC Overexpressing Neuroendocrine Prostate Cancers
por: Elhasasna, Hussain, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ghrq3jfnlioamfe5ensl14rqui