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Activation of the Medial Prefrontal Cortex Reverses Cognitive and Respiratory Symptoms in a Mouse Model of Rett Syndrome

Rett syndrome (RTT) is a severe neurodevelopmental disorder caused by loss-of-function mutations in the gene encoding methyl-CpG-binding protein 2 (MeCP2; Amir et al., 1999), a transcriptional regulatory protein (Klose et al., 2005). Mouse models of RTT (Mecp2 mutants) exhibit excitatory hypoconnect...

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Detalles Bibliográficos
Autores principales:	Howell, C. James, Sceniak, Michael P., Lang, Min, Krakowiecki, Wenceslas, Abouelsoud, Fatimah E., Lad, Saloni U., Yu, Heping, Katz, David M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Society for Neuroscience 2018
Materias:	New Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762598/ https://www.ncbi.nlm.nih.gov/pubmed/29333487 http://dx.doi.org/10.1523/ENEURO.0277-17.2017

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