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Effects on metabolic parameters in young rats born with low birth weight after exposure to a mixture of pesticides

Pesticide exposure during fetal life can lead to low birth weight and is commonly observed in reproductive toxicology studies. Associations have also been found in low birth weight babies born from pesticide-exposed gardeners. Since low birth weight is also linked to metabolic disorders, it can be s...

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Autores principales: Svingen, Terje, Ramhøj, Louise, Mandrup, Karen, Christiansen, Sofie, Axelstad, Marta, Vinggaard, Anne Marie, Hass, Ulla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762645/
https://www.ncbi.nlm.nih.gov/pubmed/29321614
http://dx.doi.org/10.1038/s41598-017-18626-x
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author Svingen, Terje
Ramhøj, Louise
Mandrup, Karen
Christiansen, Sofie
Axelstad, Marta
Vinggaard, Anne Marie
Hass, Ulla
author_facet Svingen, Terje
Ramhøj, Louise
Mandrup, Karen
Christiansen, Sofie
Axelstad, Marta
Vinggaard, Anne Marie
Hass, Ulla
author_sort Svingen, Terje
collection PubMed
description Pesticide exposure during fetal life can lead to low birth weight and is commonly observed in reproductive toxicology studies. Associations have also been found in low birth weight babies born from pesticide-exposed gardeners. Since low birth weight is also linked to metabolic disorders, it can be speculated that early life exposure to pesticides could increase the risk of becoming obese or developing diabetes later in life. We have analyzed potential long-term effects of gestational and lactational exposure to a low dose mixture of six pesticides that individually can cause low birth weight: Cyromazine, MCPB, Pirimicarb, Quinoclamine, Thiram, and Ziram. Exposed male offspring, who were smaller than controls, displayed some degree of catch-up growth. Insulin and glucagon regulation was not significantly affected, and analyses of liver and pancreas did not reveal obvious histopathological effects. Efforts towards identifying potential biomarkers of metabolic disease-risk did not result in any strong candidates, albeit leptin levels were altered in exposed animals. In fat tissues, the key genes Lep, Nmb and Nmbr were altered in high dosed offspring, and were differentially expressed between sexes. Our results suggest that early-life exposure to pesticides may contribute to the development of metabolic disorders later in life.
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spelling pubmed-57626452018-01-17 Effects on metabolic parameters in young rats born with low birth weight after exposure to a mixture of pesticides Svingen, Terje Ramhøj, Louise Mandrup, Karen Christiansen, Sofie Axelstad, Marta Vinggaard, Anne Marie Hass, Ulla Sci Rep Article Pesticide exposure during fetal life can lead to low birth weight and is commonly observed in reproductive toxicology studies. Associations have also been found in low birth weight babies born from pesticide-exposed gardeners. Since low birth weight is also linked to metabolic disorders, it can be speculated that early life exposure to pesticides could increase the risk of becoming obese or developing diabetes later in life. We have analyzed potential long-term effects of gestational and lactational exposure to a low dose mixture of six pesticides that individually can cause low birth weight: Cyromazine, MCPB, Pirimicarb, Quinoclamine, Thiram, and Ziram. Exposed male offspring, who were smaller than controls, displayed some degree of catch-up growth. Insulin and glucagon regulation was not significantly affected, and analyses of liver and pancreas did not reveal obvious histopathological effects. Efforts towards identifying potential biomarkers of metabolic disease-risk did not result in any strong candidates, albeit leptin levels were altered in exposed animals. In fat tissues, the key genes Lep, Nmb and Nmbr were altered in high dosed offspring, and were differentially expressed between sexes. Our results suggest that early-life exposure to pesticides may contribute to the development of metabolic disorders later in life. Nature Publishing Group UK 2018-01-10 /pmc/articles/PMC5762645/ /pubmed/29321614 http://dx.doi.org/10.1038/s41598-017-18626-x Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Svingen, Terje
Ramhøj, Louise
Mandrup, Karen
Christiansen, Sofie
Axelstad, Marta
Vinggaard, Anne Marie
Hass, Ulla
Effects on metabolic parameters in young rats born with low birth weight after exposure to a mixture of pesticides
title Effects on metabolic parameters in young rats born with low birth weight after exposure to a mixture of pesticides
title_full Effects on metabolic parameters in young rats born with low birth weight after exposure to a mixture of pesticides
title_fullStr Effects on metabolic parameters in young rats born with low birth weight after exposure to a mixture of pesticides
title_full_unstemmed Effects on metabolic parameters in young rats born with low birth weight after exposure to a mixture of pesticides
title_short Effects on metabolic parameters in young rats born with low birth weight after exposure to a mixture of pesticides
title_sort effects on metabolic parameters in young rats born with low birth weight after exposure to a mixture of pesticides
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762645/
https://www.ncbi.nlm.nih.gov/pubmed/29321614
http://dx.doi.org/10.1038/s41598-017-18626-x
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