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Structural ensemble-based docking simulation and biophysical studies discovered new inhibitors of Hsp90 N-terminal domain

Heat shock protein 90 (Hsp90) is one of the most abundant cellular proteins and plays a substantial role in the folding of client proteins. The inhibition of Hsp90 has been regarded as an attractive therapeutic strategy for treating cancer because many oncogenic kinases are Hsp90 client proteins. In...

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Detalles Bibliográficos
Autores principales:	Kim, Hyun-Hwi, Hyun, Ja-Shil, Choi, Joonhyeok, Choi, Kwang-Eun, Jee, Jun-Goo, Park, Sung Jean
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762686/ https://www.ncbi.nlm.nih.gov/pubmed/29321504 http://dx.doi.org/10.1038/s41598-017-18332-8

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