Cargando…

Prostaglandin E(2) Increases Lentiviral Vector Transduction Efficiency of Adult Human Hematopoietic Stem and Progenitor Cells

Gene therapy currently in development for hemoglobinopathies utilizes ex vivo lentiviral transduction of CD34(+) hematopoietic stem and progenitor cells (HSPCs). A small-molecule screen identified prostaglandin E(2) (PGE(2)) as a positive mediator of lentiviral transduction of CD34(+) cells. Supplem...

Descripción completa

Detalles Bibliográficos
Autores principales:	Heffner, Garrett C., Bonner, Melissa, Christiansen, Lauryn, Pierciey, Francis J., Campbell, Dakota, Smurnyy, Yegor, Zhang, Wenliang, Hamel, Amanda, Shaw, Seema, Lewis, Gretchen, Goss, Kendrick A., Garijo, Olivia, Torbett, Bruce E., Horton, Holly, Finer, Mitchell H., Gregory, Philip D., Veres, Gabor
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763075/ https://www.ncbi.nlm.nih.gov/pubmed/29102562 http://dx.doi.org/10.1016/j.ymthe.2017.09.025

Ejemplares similares

Staurosporine Increases Lentiviral Vector Transduction Efficiency of Human Hematopoietic Stem and Progenitor Cells
por: Lewis, Gretchen, et al.
Publicado: (2018)

Preclinical Evaluation of Efficacy and Safety of an Improved Lentiviral Vector for the Treatment of β-Thalassemia and Sickle Cell Disease
por: Negre, Olivier, et al.
Publicado: (2015)

High-Efficiency Lentiviral Transduction of Human CD34(+) Cells in High-Density Culture with Poloxamer and Prostaglandin E2
por: Uchida, Naoya, et al.
Publicado: (2019)

An optimized measles virus glycoprotein-pseudotyped lentiviral vector production system to promote efficient transduction of human primary B cells
por: Vamva, Eirini, et al.
Publicado: (2022)

Process for an efficient lentiviral cell transduction
por: Pirona, Anna Chiara, et al.
Publicado: (2020)

Driving DNA transposition by lentiviral protein transduction
por: Cai, Yujia, et al.
Publicado: (2014)

CD46 Null Packaging Cell Line Improves Measles Lentiviral Vector Production and Gene Delivery to Hematopoietic Stem and Progenitor Cells
por: Ozog, Stosh, et al.
Publicado: (2018)

Improving the Transduction of Bone Marrow–Derived Cells with an Integrase-Defective Lentiviral Vector
por: Pay, S. Louise, et al.
Publicado: (2018)

Avoiding lentiviral transduction culture induced MSC senescence
por: Pan, Yung-Wei, et al.
Publicado: (2009)

Optimized protocols for γδ T cell expansion and lentiviral transduction
por: Wang, Rui-Ning, et al.
Publicado: (2019)

Minimal impact of ZAP on lentiviral vector production and transduction efficiency
por: Sertkaya, Helin, et al.
Publicado: (2021)

Identification of a small molecule for enhancing lentiviral transduction of T cells
por: Malach, Paulina, et al.
Publicado: (2023)

Engineering fusogenic molecules to achieve targeted transduction of enveloped lentiviral vectors
por: Lei, Yuning, et al.
Publicado: (2009)

Lentiviral vector transduction of spermatozoa as a tool for the study of early development
por: Chandrashekran, Anil, et al.
Publicado: (2014)

Toward Tightly Tuned Gene Expression Following Lentiviral Vector Transduction
por: Page, Audrey, et al.
Publicado: (2020)

Cellular Proteo-Transcriptomic Changes in the Immediate Early-Phase of Lentiviral Transduction
por: Linkner, Tamás Richárd, et al.
Publicado: (2021)

Lentiviral transduction facilitates RNA interference in the nematode parasite Nippostrongylus brasiliensis
por: Hagen, Jana, et al.
Publicado: (2021)

A Nontoxic Transduction Enhancer Enables Highly Efficient Lentiviral Transduction of Primary Murine T Cells and Hematopoietic Stem Cells
por: Delville, Marianne, et al.
Publicado: (2018)

Alteration of T cell immunity by lentiviral transduction of human monocyte-derived dendritic cells
por: Chen, Xiaochuan, et al.
Publicado: (2004)

In situ transduction of stromal cells and thymocytes upon intrathymic injection of lentiviral vectors
por: Marodon, Gilles, et al.
Publicado: (2004)

Polybrene Inhibits Human Mesenchymal Stem Cell Proliferation during Lentiviral Transduction
por: Lin, Paul, et al.
Publicado: (2011)

Lentiviral Transduction of CD34(+) Cells Induces Genome-Wide Epigenetic Modifications
por: Yamagata, Yoshiaki, et al.
Publicado: (2012)

Lentiviral transduction of rat Sertoli cells as a means to modify gene expression
por: Nicholls, Peter K., et al.
Publicado: (2012)

Proteasome Inhibition Increases the Efficiency of Lentiviral Vector-Mediated Transduction of Trabecular Meshwork
por: Aktas, Zeynep, et al.
Publicado: (2018)

Enhancing Lentiviral and Alpharetroviral Transduction of Human Hematopoietic Stem Cells for Clinical Application
por: Schott, Juliane W., et al.
Publicado: (2019)

Transduction of Primary AML Cells with Lentiviral Vector for In Vitro Study or In Vivo Engraftment
por: Schimmer, Aaron D., et al.
Publicado: (2020)

Preclinical Evaluation of a Novel Lentiviral Vector Driving Lineage-Specific BCL11A Knockdown for Sickle Cell Gene Therapy
por: Brendel, Christian, et al.
Publicado: (2020)

Therapeutic protein transduction of mammalian cells and mice by nucleic acid-free lentiviral nanoparticles
por: Link, Nils, et al.
Publicado: (2006)

The Determination of Importance of Sequences Neighboring the Psi Sequence in Lentiviral Vector Transduction and Packaging Efficiency
por: Kim, Seon Hee, et al.
Publicado: (2012)

Simplified production and concentration of lentiviral vectors to achieve high transduction in primary human T cells
por: Cribbs, Adam P, et al.
Publicado: (2013)

Decitabine Suspends Human CD34(+) Cell Differentiation and Proliferation during Lentiviral Transduction
por: Uchida, Naoya, et al.
Publicado: (2014)

DNA transposition by protein transduction of the piggyBac transposase from lentiviral Gag precursors
por: Cai, Yujia, et al.
Publicado: (2014)

Targeted genome editing by lentiviral protein transduction of zinc-finger and TAL-effector nucleases
por: Cai, Yujia, et al.
Publicado: (2014)

Transduction of ferret airway epithelia using a pre-treatment and lentiviral gene vector
por: Cmielewski, Patricia, et al.
Publicado: (2014)

A Simple High Efficiency Intra-Islet Transduction Protocol Using Lentiviral Vectors
por: Jiménez-Moreno, Carmen María, et al.
Publicado: (2015)

A first experience of transduction for differentiated HepaRG cells using lentiviral technology
por: Pivert, Adeline, et al.
Publicado: (2019)

Highly efficient ex vivo lentiviral transduction of primary human pancreatic exocrine cells
por: Balak, Jeetindra R. A., et al.
Publicado: (2019)

Lentiviral vector induces high-quality memory T cells via dendritic cells transduction
por: Ku, Min Wen, et al.
Publicado: (2021)

CD9 and folate receptor overexpression are not sufficient for VSV-G-independent lentiviral transduction
por: Bellotti, Cristina, et al.
Publicado: (2022)

Computer-assisted methods for molecular structure elucidation: realizing a spectroscopist's dream
por: Elyashberg, Mikhail, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_e5ghus9243i474va29a3lsmf4l