Polyethylene Glycol for Small Bowel Capsule Endoscopy

Capsule endoscopy has been the first-line examination for small bowel diseases, yet its diagnostic yield is restricted by unsatisfactory bowel preparation. To evaluate the clinical effectiveness of different dosages of polyethylene glycol in patients undergoing capsule endoscopy, we performed a comprehensive meta-analysis of all randomized controlled trials involving polyethylene glycol in preparation for capsule endoscopy. The methodological quality of the trials was evaluated using the Cochrane Risk of Bias assessment instrument. In this study, 12 RCTs involving 2072 patients were included in this review. Our review indicated that 4 L and 2 L polyethylene (PEG) before capsule endoscopy (CE) and 500 mL PEG after CE increase the small bowel image quality, whereas 1 L PEG did not improve the small bowel image quality. PEG accelerated the gastric emptying time. There was no significant difference between the PEG group and control group in small bowel transit time, completion rates, and diagnostic yield.