RNA Aptamers Recognizing Murine CCL17 Inhibit T Cell Chemotaxis and Reduce Contact Hypersensitivity In Vivo

The chemokine CCL17, mainly produced by dendritic cells (DCs) in the immune system, is involved in the pathogenesis of various inflammatory diseases. As a ligand of CCR4, CCL17 induces chemotaxis and facilitates T cell-DC interactions. We report the identification of two novel RNA aptamers, which we...

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Detalles Bibliográficos
Autores principales: Fülle, Lorenz, Steiner, Nancy, Funke, Markus, Gondorf, Fabian, Pfeiffer, Franziska, Siegl, Julia, Opitz, Friederike V., Haßel, Silvana K., Erazo, Anna Belen, Schanz, Oliver, Stunden, H. James, Blank, Michael, Gröber, Carsten, Händler, Kristian, Beyer, Marc, Weighardt, Heike, Latz, Eicke, Schultze, Joachim L., Mayer, Günter, Förster, Irmgard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763148/
https://www.ncbi.nlm.nih.gov/pubmed/29103909
http://dx.doi.org/10.1016/j.ymthe.2017.10.005

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