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Follicular thyroid cancer avid on C-11 Methionine PET/CT

A case of follicular thyroid cancer with intense focal Methionine uptake on 11C-Methionine PET/CT is reported here. The use of 11C-Methionine PET in differentiated thyroid cancer is currently being investigated as a surrogate tracer compared to the more widely used 18F-FDG PET. This case illustrates...

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Autores principales: Jochumsen, Mads Ryø, Iversen, Peter, Arveschoug, Anne Kirstine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763279/
https://www.ncbi.nlm.nih.gov/pubmed/29340158
http://dx.doi.org/10.1530/EDM-17-0151
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author Jochumsen, Mads Ryø
Iversen, Peter
Arveschoug, Anne Kirstine
author_facet Jochumsen, Mads Ryø
Iversen, Peter
Arveschoug, Anne Kirstine
author_sort Jochumsen, Mads Ryø
collection PubMed
description A case of follicular thyroid cancer with intense focal Methionine uptake on 11C-Methionine PET/CT is reported here. The use of 11C-Methionine PET in differentiated thyroid cancer is currently being investigated as a surrogate tracer compared to the more widely used 18F-FDG PET. This case illustrates the potential incremental value of this modality, not only in the localizing of parathyroid adenoma, but also indicating that 11C-Methionine PET might have a potential of increasing the pretest likelihood of thyroid malignancy in a cold nodule with highly increased Sestamibi uptake. LEARNING POINTS: 11C-Methionine PET/CT and 18F-Fluorocholine PET/CT often visualizes the parathyroid adenoma in case of negative Tc-99m-MIBI SPECT/CT. A cold nodule in Tc-99m Pertechnetat thyroid scintigraphy with a negative Sestamibi scintigraphy has a very low probability of being malignant. However, the pretest likelihood of thyroid cancer in a cold nodule with increased Sestamibi uptake is low. 11C-Methionine PET might have a potential incremental value in increasing the pretest likelihood of thyroid malignancy in a cold nodule with highly increased Sestamibi uptake.
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spelling pubmed-57632792018-01-16 Follicular thyroid cancer avid on C-11 Methionine PET/CT Jochumsen, Mads Ryø Iversen, Peter Arveschoug, Anne Kirstine Endocrinol Diabetes Metab Case Rep Novel Diagnostic Procedure A case of follicular thyroid cancer with intense focal Methionine uptake on 11C-Methionine PET/CT is reported here. The use of 11C-Methionine PET in differentiated thyroid cancer is currently being investigated as a surrogate tracer compared to the more widely used 18F-FDG PET. This case illustrates the potential incremental value of this modality, not only in the localizing of parathyroid adenoma, but also indicating that 11C-Methionine PET might have a potential of increasing the pretest likelihood of thyroid malignancy in a cold nodule with highly increased Sestamibi uptake. LEARNING POINTS: 11C-Methionine PET/CT and 18F-Fluorocholine PET/CT often visualizes the parathyroid adenoma in case of negative Tc-99m-MIBI SPECT/CT. A cold nodule in Tc-99m Pertechnetat thyroid scintigraphy with a negative Sestamibi scintigraphy has a very low probability of being malignant. However, the pretest likelihood of thyroid cancer in a cold nodule with increased Sestamibi uptake is low. 11C-Methionine PET might have a potential incremental value in increasing the pretest likelihood of thyroid malignancy in a cold nodule with highly increased Sestamibi uptake. Bioscientifica Ltd 2018-01-05 /pmc/articles/PMC5763279/ /pubmed/29340158 http://dx.doi.org/10.1530/EDM-17-0151 Text en © 2018 The authors http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en_GB This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en_GB) .
spellingShingle Novel Diagnostic Procedure
Jochumsen, Mads Ryø
Iversen, Peter
Arveschoug, Anne Kirstine
Follicular thyroid cancer avid on C-11 Methionine PET/CT
title Follicular thyroid cancer avid on C-11 Methionine PET/CT
title_full Follicular thyroid cancer avid on C-11 Methionine PET/CT
title_fullStr Follicular thyroid cancer avid on C-11 Methionine PET/CT
title_full_unstemmed Follicular thyroid cancer avid on C-11 Methionine PET/CT
title_short Follicular thyroid cancer avid on C-11 Methionine PET/CT
title_sort follicular thyroid cancer avid on c-11 methionine pet/ct
topic Novel Diagnostic Procedure
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763279/
https://www.ncbi.nlm.nih.gov/pubmed/29340158
http://dx.doi.org/10.1530/EDM-17-0151
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