Constraint-based perturbation analysis with cluster Newton method: a case study of personalized parameter estimations with irinotecan whole-body physiologically based pharmacokinetic model

BACKGROUND: Drug development considering individual varieties among patients becomes crucial to improve clinical development success rates and save healthcare costs. As a useful tool to predict individual phenomena and correlations among drug characteristics and individual varieties, recently, whole...

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Detalles Bibliográficos
Autores principales: Asami, Shun, Kiga, Daisuke, Konagaya, Akihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763286/
https://www.ncbi.nlm.nih.gov/pubmed/29322928
http://dx.doi.org/10.1186/s12918-017-0513-2

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