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Computational analysis reveals the coupling between bistability and the sign of a feedback loop in a TGF-β1 activation model
BACKGROUND: Bistable behaviors are prevalent in cell signaling and can be modeled by ordinary differential equations (ODEs) with kinetic parameters. A bistable switch has recently been found to regulate the activation of transforming growth factor-β1 (TGF-β1) in the context of liver fibrosis, and an...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763301/ https://www.ncbi.nlm.nih.gov/pubmed/29322934 http://dx.doi.org/10.1186/s12918-017-0508-z |