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Long-term follow-up of retinoblastoma survivors: Experience from India
BACKGROUND: Retinoblastoma (Rb) is the most common primary intraocular tumor of infancy and childhood. Survivors’ ocular and visual problems and increased risk for subsequent malignancy are well documented, but data on long-term health status of Rb survivors are limited, this being particularly true...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763631/ https://www.ncbi.nlm.nih.gov/pubmed/29404299 http://dx.doi.org/10.4103/sajc.sajc_179_16 |
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author | Seth, Rachna Singh, Amitabh Guru, Vijay Chawla, Bhavna Pathy, Sushmita Sapra, Savita |
author_facet | Seth, Rachna Singh, Amitabh Guru, Vijay Chawla, Bhavna Pathy, Sushmita Sapra, Savita |
author_sort | Seth, Rachna |
collection | PubMed |
description | BACKGROUND: Retinoblastoma (Rb) is the most common primary intraocular tumor of infancy and childhood. Survivors’ ocular and visual problems and increased risk for subsequent malignancy are well documented, but data on long-term health status of Rb survivors are limited, this being particularly true for India. METHODOLOGY: Children who had completed treatment for Rb at least 2 years ago before and were under follow-up at the after cancer treatment clinic were evaluated. RESULTS: In our series of 213 patients, the median age was 29 months, there was a male preponderance, and majority had unilateral disease. Enucleation was done in almost three-fourth and 3% underwent bilateral enucleation. Majority of the patients received chemotherapy, and few received radiation. Growth was affected in about one-third and majority were those who had received radiation. Diminished vision was noticed in about one-sixth. Orbital hypoplasia and contracted socket were seen in 14.1% cases. 2.7% were hearing impaired. About one-sixth had a global intelligence delay. Second neoplasms were seen in 0.01%. No other abnormalities were seen. CONCLUSIONS: Common late effects in our Rb survivors include diminished vision in the salvage eye, intellectual disability, and contracted socket; there is a need for timely institution of prosthesis to avoid late effects such as hypoplasia, contracted sockets, and better cosmesis and enhanced self-esteem. Second neoplasm is a concern. Lifelong follow-up and counseling of a healthy lifestyle are needed for Rb survivors. |
format | Online Article Text |
id | pubmed-5763631 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-57636312018-02-05 Long-term follow-up of retinoblastoma survivors: Experience from India Seth, Rachna Singh, Amitabh Guru, Vijay Chawla, Bhavna Pathy, Sushmita Sapra, Savita South Asian J Cancer ORIGINAL ARTICLE: Pediatric and Adolescent Cancers BACKGROUND: Retinoblastoma (Rb) is the most common primary intraocular tumor of infancy and childhood. Survivors’ ocular and visual problems and increased risk for subsequent malignancy are well documented, but data on long-term health status of Rb survivors are limited, this being particularly true for India. METHODOLOGY: Children who had completed treatment for Rb at least 2 years ago before and were under follow-up at the after cancer treatment clinic were evaluated. RESULTS: In our series of 213 patients, the median age was 29 months, there was a male preponderance, and majority had unilateral disease. Enucleation was done in almost three-fourth and 3% underwent bilateral enucleation. Majority of the patients received chemotherapy, and few received radiation. Growth was affected in about one-third and majority were those who had received radiation. Diminished vision was noticed in about one-sixth. Orbital hypoplasia and contracted socket were seen in 14.1% cases. 2.7% were hearing impaired. About one-sixth had a global intelligence delay. Second neoplasms were seen in 0.01%. No other abnormalities were seen. CONCLUSIONS: Common late effects in our Rb survivors include diminished vision in the salvage eye, intellectual disability, and contracted socket; there is a need for timely institution of prosthesis to avoid late effects such as hypoplasia, contracted sockets, and better cosmesis and enhanced self-esteem. Second neoplasm is a concern. Lifelong follow-up and counseling of a healthy lifestyle are needed for Rb survivors. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5763631/ /pubmed/29404299 http://dx.doi.org/10.4103/sajc.sajc_179_16 Text en Copyright: © 2017 The South Asian Journal of Cancer http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | ORIGINAL ARTICLE: Pediatric and Adolescent Cancers Seth, Rachna Singh, Amitabh Guru, Vijay Chawla, Bhavna Pathy, Sushmita Sapra, Savita Long-term follow-up of retinoblastoma survivors: Experience from India |
title | Long-term follow-up of retinoblastoma survivors: Experience from India |
title_full | Long-term follow-up of retinoblastoma survivors: Experience from India |
title_fullStr | Long-term follow-up of retinoblastoma survivors: Experience from India |
title_full_unstemmed | Long-term follow-up of retinoblastoma survivors: Experience from India |
title_short | Long-term follow-up of retinoblastoma survivors: Experience from India |
title_sort | long-term follow-up of retinoblastoma survivors: experience from india |
topic | ORIGINAL ARTICLE: Pediatric and Adolescent Cancers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763631/ https://www.ncbi.nlm.nih.gov/pubmed/29404299 http://dx.doi.org/10.4103/sajc.sajc_179_16 |
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