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The effects of essential oil mouthrinses with or without alcohol on plaque and gingivitis: a randomized controlled clinical study
BACKGROUND: The efficacy of several variants of essential oil mouthrinses has been studied extensively. This is the first study to compare the anti-plaque and anti-gingivitis efficacy of two marketed essential oil mouthrinses: one is an alcohol containing mouthrinse and the other one is an alcohol-f...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763666/ https://www.ncbi.nlm.nih.gov/pubmed/29321067 http://dx.doi.org/10.1186/s12903-017-0454-6 |
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author | Lynch, Michael C. Cortelli, Sheila Cavalca McGuire, James A. Zhang, Jane Ricci-Nittel, Danette Mordas, Carolyn J. Aquino, Davi Romeiro Cortelli, Jose Roberto |
author_facet | Lynch, Michael C. Cortelli, Sheila Cavalca McGuire, James A. Zhang, Jane Ricci-Nittel, Danette Mordas, Carolyn J. Aquino, Davi Romeiro Cortelli, Jose Roberto |
author_sort | Lynch, Michael C. |
collection | PubMed |
description | BACKGROUND: The efficacy of several variants of essential oil mouthrinses has been studied extensively. This is the first study to compare the anti-plaque and anti-gingivitis efficacy of two marketed essential oil mouthrinses: one is an alcohol containing mouthrinse and the other one is an alcohol-free mouthrinse. METHODS: This examiner-blind, parallel-group study randomized subjects to three groups: 1) Mechanical Oral Hygiene (MOH) only; 2) MOH plus Alcohol-Containing essential oil Mouthrinse (ACM); 3) MOH plus Alcohol-Free essential oil Mouthrinse (AFM). Primary endpoint was whole-mouth mean Modified Gingival Index (MGI) at six months. Secondary endpoints included whole-mouth mean MGI at one and three months, and whole-mouth mean Plaque Index (PI) and whole-mouth mean Bleeding Index (BI) at one, three and six months. Safety assessments were conducted at all time points. RESULTS: A total of 370 subjects were enrolled; 348 subjects completed the study. After six months, subjects using essential oil mouthrinses with or without alcohol showed significant reduction (p < 0.001) in gingivitis (28.2% and 26.7%, respectively) and significant reduction (p < 0.001) in plaque (37.8% and 37.0%, respectively), compared to those performing MOH only. Significant reductions in MGI, PI, and BI (p < 0.001) were observed at one and three months and also at six months for mean BI. No statistically significant differences were observed for all measured indices between ACM and AFM groups at any time point. Both mouthrinses were well tolerated. CONCLUSIONS: No significant differences were observed in the efficacy of ACM and AFM to reduce plaque and gingivitis, when used in addition to MOH, over six months. TRIAL REGISTRATION: The trial was registered on clinicaltrials.gov on November 30, 2016. The registration number is NCT02980497. |
format | Online Article Text |
id | pubmed-5763666 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-57636662018-01-17 The effects of essential oil mouthrinses with or without alcohol on plaque and gingivitis: a randomized controlled clinical study Lynch, Michael C. Cortelli, Sheila Cavalca McGuire, James A. Zhang, Jane Ricci-Nittel, Danette Mordas, Carolyn J. Aquino, Davi Romeiro Cortelli, Jose Roberto BMC Oral Health Research Article BACKGROUND: The efficacy of several variants of essential oil mouthrinses has been studied extensively. This is the first study to compare the anti-plaque and anti-gingivitis efficacy of two marketed essential oil mouthrinses: one is an alcohol containing mouthrinse and the other one is an alcohol-free mouthrinse. METHODS: This examiner-blind, parallel-group study randomized subjects to three groups: 1) Mechanical Oral Hygiene (MOH) only; 2) MOH plus Alcohol-Containing essential oil Mouthrinse (ACM); 3) MOH plus Alcohol-Free essential oil Mouthrinse (AFM). Primary endpoint was whole-mouth mean Modified Gingival Index (MGI) at six months. Secondary endpoints included whole-mouth mean MGI at one and three months, and whole-mouth mean Plaque Index (PI) and whole-mouth mean Bleeding Index (BI) at one, three and six months. Safety assessments were conducted at all time points. RESULTS: A total of 370 subjects were enrolled; 348 subjects completed the study. After six months, subjects using essential oil mouthrinses with or without alcohol showed significant reduction (p < 0.001) in gingivitis (28.2% and 26.7%, respectively) and significant reduction (p < 0.001) in plaque (37.8% and 37.0%, respectively), compared to those performing MOH only. Significant reductions in MGI, PI, and BI (p < 0.001) were observed at one and three months and also at six months for mean BI. No statistically significant differences were observed for all measured indices between ACM and AFM groups at any time point. Both mouthrinses were well tolerated. CONCLUSIONS: No significant differences were observed in the efficacy of ACM and AFM to reduce plaque and gingivitis, when used in addition to MOH, over six months. TRIAL REGISTRATION: The trial was registered on clinicaltrials.gov on November 30, 2016. The registration number is NCT02980497. BioMed Central 2018-01-10 /pmc/articles/PMC5763666/ /pubmed/29321067 http://dx.doi.org/10.1186/s12903-017-0454-6 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Lynch, Michael C. Cortelli, Sheila Cavalca McGuire, James A. Zhang, Jane Ricci-Nittel, Danette Mordas, Carolyn J. Aquino, Davi Romeiro Cortelli, Jose Roberto The effects of essential oil mouthrinses with or without alcohol on plaque and gingivitis: a randomized controlled clinical study |
title | The effects of essential oil mouthrinses with or without alcohol on plaque and gingivitis: a randomized controlled clinical study |
title_full | The effects of essential oil mouthrinses with or without alcohol on plaque and gingivitis: a randomized controlled clinical study |
title_fullStr | The effects of essential oil mouthrinses with or without alcohol on plaque and gingivitis: a randomized controlled clinical study |
title_full_unstemmed | The effects of essential oil mouthrinses with or without alcohol on plaque and gingivitis: a randomized controlled clinical study |
title_short | The effects of essential oil mouthrinses with or without alcohol on plaque and gingivitis: a randomized controlled clinical study |
title_sort | effects of essential oil mouthrinses with or without alcohol on plaque and gingivitis: a randomized controlled clinical study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763666/ https://www.ncbi.nlm.nih.gov/pubmed/29321067 http://dx.doi.org/10.1186/s12903-017-0454-6 |
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