Hepatocyte Growth Factor in Synaptic Plasticity and Alzheimer's Disease

The hepatocyte growth factor (HGF) was initially identified as a protein that promoted growth of hepatocytes. It regulates proliferation and survival of different types of cells. HGF signaling, which is initiated by its binding to a receptor tyrosine kinase, plays critical roles during development....

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Detalles Bibliográficos
Autor principal: Sharma, Shiv K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2010
Materias:
Mini-Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763803/
https://www.ncbi.nlm.nih.gov/pubmed/20305987
http://dx.doi.org/10.1100/tsw.2010.49
Descripción
Sumario:The hepatocyte growth factor (HGF) was initially identified as a protein that promoted growth of hepatocytes. It regulates proliferation and survival of different types of cells. HGF signaling, which is initiated by its binding to a receptor tyrosine kinase, plays critical roles during development. HGF and its receptor are also present in brain cells. This review describes the role of HGF in hippocampal neurons, synaptic plasticity, and the memory impairment condition, Alzheimer's disease.

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