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Hepatocyte Growth Factor in Synaptic Plasticity and Alzheimer's Disease
The hepatocyte growth factor (HGF) was initially identified as a protein that promoted growth of hepatocytes. It regulates proliferation and survival of different types of cells. HGF signaling, which is initiated by its binding to a receptor tyrosine kinase, plays critical roles during development....
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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TheScientificWorldJOURNAL
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763803/ https://www.ncbi.nlm.nih.gov/pubmed/20305987 http://dx.doi.org/10.1100/tsw.2010.49 |
| _version_ | 1783291955571064832 |
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| author | Sharma, Shiv K. |
| author_facet | Sharma, Shiv K. |
| author_sort | Sharma, Shiv K. |
| collection | PubMed |
| description | The hepatocyte growth factor (HGF) was initially identified as a protein that promoted growth of hepatocytes. It regulates proliferation and survival of different types of cells. HGF signaling, which is initiated by its binding to a receptor tyrosine kinase, plays critical roles during development. HGF and its receptor are also present in brain cells. This review describes the role of HGF in hippocampal neurons, synaptic plasticity, and the memory impairment condition, Alzheimer's disease. |
| format | Online Article Text |
| id | pubmed-5763803 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2010 |
| publisher | TheScientificWorldJOURNAL |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-57638032018-06-03 Hepatocyte Growth Factor in Synaptic Plasticity and Alzheimer's Disease Sharma, Shiv K. ScientificWorldJournal Mini-Review Article The hepatocyte growth factor (HGF) was initially identified as a protein that promoted growth of hepatocytes. It regulates proliferation and survival of different types of cells. HGF signaling, which is initiated by its binding to a receptor tyrosine kinase, plays critical roles during development. HGF and its receptor are also present in brain cells. This review describes the role of HGF in hippocampal neurons, synaptic plasticity, and the memory impairment condition, Alzheimer's disease. TheScientificWorldJOURNAL 2010-03-16 /pmc/articles/PMC5763803/ /pubmed/20305987 http://dx.doi.org/10.1100/tsw.2010.49 Text en Copyright © 2010 Shiv K. Sharma. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Mini-Review Article Sharma, Shiv K. Hepatocyte Growth Factor in Synaptic Plasticity and Alzheimer's Disease |
| title | Hepatocyte Growth Factor in Synaptic Plasticity and Alzheimer's Disease |
| title_full | Hepatocyte Growth Factor in Synaptic Plasticity and Alzheimer's Disease |
| title_fullStr | Hepatocyte Growth Factor in Synaptic Plasticity and Alzheimer's Disease |
| title_full_unstemmed | Hepatocyte Growth Factor in Synaptic Plasticity and Alzheimer's Disease |
| title_short | Hepatocyte Growth Factor in Synaptic Plasticity and Alzheimer's Disease |
| title_sort | hepatocyte growth factor in synaptic plasticity and alzheimer's disease |
| topic | Mini-Review Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763803/ https://www.ncbi.nlm.nih.gov/pubmed/20305987 http://dx.doi.org/10.1100/tsw.2010.49 |
| work_keys_str_mv | AT sharmashivk hepatocytegrowthfactorinsynapticplasticityandalzheimersdisease |