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Natural Catalytic Antibodies in Norm, Autoimmune, Viral, and Bacterial Diseases

In human patients with autoimmune, viral, and bacterial diseases, the generation of antibodies (Abs) to foreign antigens and/or autoantibodies to self-antigens usually occurs. Some Abs with different catalytic activities (abzymes, Abzs) may be induced spontaneously by primary antigens and can have c...

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Autores principales: Nevinsky, Georgy A., Buneva, Valentina N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763945/
https://www.ncbi.nlm.nih.gov/pubmed/20602079
http://dx.doi.org/10.1100/tsw.2010.98
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author Nevinsky, Georgy A.
Buneva, Valentina N.
author_facet Nevinsky, Georgy A.
Buneva, Valentina N.
author_sort Nevinsky, Georgy A.
collection PubMed
description In human patients with autoimmune, viral, and bacterial diseases, the generation of antibodies (Abs) to foreign antigens and/or autoantibodies to self-antigens usually occurs. Some Abs with different catalytic activities (abzymes, Abzs) may be induced spontaneously by primary antigens and can have characteristics of the primary antigen, including the catalytic activity of idiotypic and/or anti-idiotypic Abs. Healthy humans usually do not develop Abzs or their activities are low, often on the borderline of sensitivity of the detection methods. Detection of Abzs was shown to be the earliest indicator of development of different autoimmune diseases (ADs). At the early stages of ADs, the repertoire of Abzs is usually relatively narrow, but it greatly expands with the progress of the disease, leading to the generation of catalytically diverse Abzs with different activities and functions. Some Abzs are cytotoxic and can play an important negative role in the pathogenesis of ADs, while positive roles have been proposed for other Abzs. Abzs with some low activities can temporarily be present in the blood of patients in the course of viral and bacterial diseases, but their activity increases significantly if these infections stimulate development of ADs. A significant increase in the relative Abz activities associated with a specific reorganization of the immune system, including changes in the differentiation and proliferation of bone marrow hematopoietic stem cells and lymphocyte proliferation in different organs. Different mechanisms of Abz production can be proposed for healthy externally immunized and for autoimmune mammals during the development of pathology.
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spelling pubmed-57639452018-06-03 Natural Catalytic Antibodies in Norm, Autoimmune, Viral, and Bacterial Diseases Nevinsky, Georgy A. Buneva, Valentina N. ScientificWorldJournal Mini-Review Article In human patients with autoimmune, viral, and bacterial diseases, the generation of antibodies (Abs) to foreign antigens and/or autoantibodies to self-antigens usually occurs. Some Abs with different catalytic activities (abzymes, Abzs) may be induced spontaneously by primary antigens and can have characteristics of the primary antigen, including the catalytic activity of idiotypic and/or anti-idiotypic Abs. Healthy humans usually do not develop Abzs or their activities are low, often on the borderline of sensitivity of the detection methods. Detection of Abzs was shown to be the earliest indicator of development of different autoimmune diseases (ADs). At the early stages of ADs, the repertoire of Abzs is usually relatively narrow, but it greatly expands with the progress of the disease, leading to the generation of catalytically diverse Abzs with different activities and functions. Some Abzs are cytotoxic and can play an important negative role in the pathogenesis of ADs, while positive roles have been proposed for other Abzs. Abzs with some low activities can temporarily be present in the blood of patients in the course of viral and bacterial diseases, but their activity increases significantly if these infections stimulate development of ADs. A significant increase in the relative Abz activities associated with a specific reorganization of the immune system, including changes in the differentiation and proliferation of bone marrow hematopoietic stem cells and lymphocyte proliferation in different organs. Different mechanisms of Abz production can be proposed for healthy externally immunized and for autoimmune mammals during the development of pathology. TheScientificWorldJOURNAL 2010-06-29 /pmc/articles/PMC5763945/ /pubmed/20602079 http://dx.doi.org/10.1100/tsw.2010.98 Text en Copyright © 2010 Georgy A. Nevinsky and Valentina N. Buneva. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Mini-Review Article
Nevinsky, Georgy A.
Buneva, Valentina N.
Natural Catalytic Antibodies in Norm, Autoimmune, Viral, and Bacterial Diseases
title Natural Catalytic Antibodies in Norm, Autoimmune, Viral, and Bacterial Diseases
title_full Natural Catalytic Antibodies in Norm, Autoimmune, Viral, and Bacterial Diseases
title_fullStr Natural Catalytic Antibodies in Norm, Autoimmune, Viral, and Bacterial Diseases
title_full_unstemmed Natural Catalytic Antibodies in Norm, Autoimmune, Viral, and Bacterial Diseases
title_short Natural Catalytic Antibodies in Norm, Autoimmune, Viral, and Bacterial Diseases
title_sort natural catalytic antibodies in norm, autoimmune, viral, and bacterial diseases
topic Mini-Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763945/
https://www.ncbi.nlm.nih.gov/pubmed/20602079
http://dx.doi.org/10.1100/tsw.2010.98
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