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Stress Proteins and Pancreatic Cancer Metastasis
Tumor metastasis is challenged by its resistance to microenvironmental stress infringed during escape from the primary tumor and the colonization of a foreign secondary tissue. Because of its great metastatic potential and its strong resistance to anticancer drugs, pancreatic cancer is regarded as a...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
TheScientificWorldJOURNAL
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763959/ https://www.ncbi.nlm.nih.gov/pubmed/20890585 http://dx.doi.org/10.1100/tsw.2010.186 |
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author | Cano, Carla E. Iovanna, Juan L. |
author_facet | Cano, Carla E. Iovanna, Juan L. |
author_sort | Cano, Carla E. |
collection | PubMed |
description | Tumor metastasis is challenged by its resistance to microenvironmental stress infringed during escape from the primary tumor and the colonization of a foreign secondary tissue. Because of its great metastatic potential and its strong resistance to anticancer drugs, pancreatic cancer is regarded as a paradigm of the adaptation of cancer cells to microenvironmental stress. Thus, to understand how pancreatic cancer cells adapt to the different endogenous and therapy-related stresses is crucial for understanding their etiology and for the development of new efficient anticancer strategies. This review summarizes the multiple functions accomplished by one major factor of pancreatic cancer cell stress response, the stress protein p8. |
format | Online Article Text |
id | pubmed-5763959 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | TheScientificWorldJOURNAL |
record_format | MEDLINE/PubMed |
spelling | pubmed-57639592018-06-03 Stress Proteins and Pancreatic Cancer Metastasis Cano, Carla E. Iovanna, Juan L. ScientificWorldJournal Review Article Tumor metastasis is challenged by its resistance to microenvironmental stress infringed during escape from the primary tumor and the colonization of a foreign secondary tissue. Because of its great metastatic potential and its strong resistance to anticancer drugs, pancreatic cancer is regarded as a paradigm of the adaptation of cancer cells to microenvironmental stress. Thus, to understand how pancreatic cancer cells adapt to the different endogenous and therapy-related stresses is crucial for understanding their etiology and for the development of new efficient anticancer strategies. This review summarizes the multiple functions accomplished by one major factor of pancreatic cancer cell stress response, the stress protein p8. TheScientificWorldJOURNAL 2010-10-01 /pmc/articles/PMC5763959/ /pubmed/20890585 http://dx.doi.org/10.1100/tsw.2010.186 Text en Copyright © 2010 Carla E. Cano and Juan L. Iovanna. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Cano, Carla E. Iovanna, Juan L. Stress Proteins and Pancreatic Cancer Metastasis |
title | Stress Proteins and Pancreatic Cancer Metastasis |
title_full | Stress Proteins and Pancreatic Cancer Metastasis |
title_fullStr | Stress Proteins and Pancreatic Cancer Metastasis |
title_full_unstemmed | Stress Proteins and Pancreatic Cancer Metastasis |
title_short | Stress Proteins and Pancreatic Cancer Metastasis |
title_sort | stress proteins and pancreatic cancer metastasis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763959/ https://www.ncbi.nlm.nih.gov/pubmed/20890585 http://dx.doi.org/10.1100/tsw.2010.186 |
work_keys_str_mv | AT canocarlae stressproteinsandpancreaticcancermetastasis AT iovannajuanl stressproteinsandpancreaticcancermetastasis |