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Regulation of Skp2 Expression and Activity and Its Role in Cancer Progression

The regulation of cell cycle entry is critical for cell proliferation and tumorigenesis. One of the key players regulating cell cycle progression is the F-box protein Skp2. Skp2 forms a SCF complex with Skp1, Cul-1, and Rbx1 to constitute E3 ligase through its F-box domain. Skp2 protein levels are r...

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Detalles Bibliográficos
Autores principales:	Chan, Chia-Hsin, Lee, Szu-Wei, Wang, Jing, Lin, Hui-Kuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	TheScientificWorldJOURNAL 2010
Materias:	Mini-Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763972/ https://www.ncbi.nlm.nih.gov/pubmed/20526532 http://dx.doi.org/10.1100/tsw.2010.89

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