Cargando…
Urothelial Cancer Stem Cells
There is mounting evidence supporting the idea that tumors, similar to normal adult tissues, arise from a specific stem-like cell population, the cancer stem cells (CSCs), which are considered as the real driving force behind tumor growth, the ability to metastasize, as well as resistance to convent...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
TheScientificWorldJOURNAL
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763978/ https://www.ncbi.nlm.nih.gov/pubmed/20661533 http://dx.doi.org/10.1100/tsw.2010.138 |
_version_ | 1783291991073751040 |
---|---|
author | Dimov, Irena Visnjic, Milan Stefanovic, Vladisav |
author_facet | Dimov, Irena Visnjic, Milan Stefanovic, Vladisav |
author_sort | Dimov, Irena |
collection | PubMed |
description | There is mounting evidence supporting the idea that tumors, similar to normal adult tissues, arise from a specific stem-like cell population, the cancer stem cells (CSCs), which are considered as the real driving force behind tumor growth, the ability to metastasize, as well as resistance to conventional antitumor therapy. The concept that cancer growth recapitulates normal proliferative and/or regenerative processes, even though in very dysfunctional ways, has tremendous implications for cancer therapy. The rapid development of the CSC field, shoulder to shoulder with powerful genome-wide screening techniques, has provided cause for optimism for the development of more reliable therapies in the future. However, several important issues still lie ahead. Recent identification of a highly tumorigenic stem-like compartment and existence of urothelial differentiation programs in urothelial cell carcinomas (UCCs) raised important questions about UCC initiation and development. This review examines the present knowledge on CSCs in UCCs regarding the similarities between CSCs and the adult urothelial stem cells, potential origin of urothelial CSCs, main regulatory pathways, surface markers expression, and the current state of CSC-targeting therapeutic strategies. |
format | Online Article Text |
id | pubmed-5763978 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | TheScientificWorldJOURNAL |
record_format | MEDLINE/PubMed |
spelling | pubmed-57639782018-06-03 Urothelial Cancer Stem Cells Dimov, Irena Visnjic, Milan Stefanovic, Vladisav ScientificWorldJournal Review Article There is mounting evidence supporting the idea that tumors, similar to normal adult tissues, arise from a specific stem-like cell population, the cancer stem cells (CSCs), which are considered as the real driving force behind tumor growth, the ability to metastasize, as well as resistance to conventional antitumor therapy. The concept that cancer growth recapitulates normal proliferative and/or regenerative processes, even though in very dysfunctional ways, has tremendous implications for cancer therapy. The rapid development of the CSC field, shoulder to shoulder with powerful genome-wide screening techniques, has provided cause for optimism for the development of more reliable therapies in the future. However, several important issues still lie ahead. Recent identification of a highly tumorigenic stem-like compartment and existence of urothelial differentiation programs in urothelial cell carcinomas (UCCs) raised important questions about UCC initiation and development. This review examines the present knowledge on CSCs in UCCs regarding the similarities between CSCs and the adult urothelial stem cells, potential origin of urothelial CSCs, main regulatory pathways, surface markers expression, and the current state of CSC-targeting therapeutic strategies. TheScientificWorldJOURNAL 2010-07-20 /pmc/articles/PMC5763978/ /pubmed/20661533 http://dx.doi.org/10.1100/tsw.2010.138 Text en Copyright © 2010 Irena Dimov et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Dimov, Irena Visnjic, Milan Stefanovic, Vladisav Urothelial Cancer Stem Cells |
title | Urothelial Cancer Stem Cells |
title_full | Urothelial Cancer Stem Cells |
title_fullStr | Urothelial Cancer Stem Cells |
title_full_unstemmed | Urothelial Cancer Stem Cells |
title_short | Urothelial Cancer Stem Cells |
title_sort | urothelial cancer stem cells |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763978/ https://www.ncbi.nlm.nih.gov/pubmed/20661533 http://dx.doi.org/10.1100/tsw.2010.138 |
work_keys_str_mv | AT dimovirena urothelialcancerstemcells AT visnjicmilan urothelialcancerstemcells AT stefanovicvladisav urothelialcancerstemcells |