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Urothelial Cancer Stem Cells

There is mounting evidence supporting the idea that tumors, similar to normal adult tissues, arise from a specific stem-like cell population, the cancer stem cells (CSCs), which are considered as the real driving force behind tumor growth, the ability to metastasize, as well as resistance to convent...

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Detalles Bibliográficos
Autores principales: Dimov, Irena, Visnjic, Milan, Stefanovic, Vladisav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763978/
https://www.ncbi.nlm.nih.gov/pubmed/20661533
http://dx.doi.org/10.1100/tsw.2010.138
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author Dimov, Irena
Visnjic, Milan
Stefanovic, Vladisav
author_facet Dimov, Irena
Visnjic, Milan
Stefanovic, Vladisav
author_sort Dimov, Irena
collection PubMed
description There is mounting evidence supporting the idea that tumors, similar to normal adult tissues, arise from a specific stem-like cell population, the cancer stem cells (CSCs), which are considered as the real driving force behind tumor growth, the ability to metastasize, as well as resistance to conventional antitumor therapy. The concept that cancer growth recapitulates normal proliferative and/or regenerative processes, even though in very dysfunctional ways, has tremendous implications for cancer therapy. The rapid development of the CSC field, shoulder to shoulder with powerful genome-wide screening techniques, has provided cause for optimism for the development of more reliable therapies in the future. However, several important issues still lie ahead. Recent identification of a highly tumorigenic stem-like compartment and existence of urothelial differentiation programs in urothelial cell carcinomas (UCCs) raised important questions about UCC initiation and development. This review examines the present knowledge on CSCs in UCCs regarding the similarities between CSCs and the adult urothelial stem cells, potential origin of urothelial CSCs, main regulatory pathways, surface markers expression, and the current state of CSC-targeting therapeutic strategies.
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spelling pubmed-57639782018-06-03 Urothelial Cancer Stem Cells Dimov, Irena Visnjic, Milan Stefanovic, Vladisav ScientificWorldJournal Review Article There is mounting evidence supporting the idea that tumors, similar to normal adult tissues, arise from a specific stem-like cell population, the cancer stem cells (CSCs), which are considered as the real driving force behind tumor growth, the ability to metastasize, as well as resistance to conventional antitumor therapy. The concept that cancer growth recapitulates normal proliferative and/or regenerative processes, even though in very dysfunctional ways, has tremendous implications for cancer therapy. The rapid development of the CSC field, shoulder to shoulder with powerful genome-wide screening techniques, has provided cause for optimism for the development of more reliable therapies in the future. However, several important issues still lie ahead. Recent identification of a highly tumorigenic stem-like compartment and existence of urothelial differentiation programs in urothelial cell carcinomas (UCCs) raised important questions about UCC initiation and development. This review examines the present knowledge on CSCs in UCCs regarding the similarities between CSCs and the adult urothelial stem cells, potential origin of urothelial CSCs, main regulatory pathways, surface markers expression, and the current state of CSC-targeting therapeutic strategies. TheScientificWorldJOURNAL 2010-07-20 /pmc/articles/PMC5763978/ /pubmed/20661533 http://dx.doi.org/10.1100/tsw.2010.138 Text en Copyright © 2010 Irena Dimov et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Dimov, Irena
Visnjic, Milan
Stefanovic, Vladisav
Urothelial Cancer Stem Cells
title Urothelial Cancer Stem Cells
title_full Urothelial Cancer Stem Cells
title_fullStr Urothelial Cancer Stem Cells
title_full_unstemmed Urothelial Cancer Stem Cells
title_short Urothelial Cancer Stem Cells
title_sort urothelial cancer stem cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763978/
https://www.ncbi.nlm.nih.gov/pubmed/20661533
http://dx.doi.org/10.1100/tsw.2010.138
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