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A phase I, open-label trial on the safety and immunogenicity of the adjuvanted tuberculosis subunit vaccine H1/IC31® in people living in a TB-endemic area

BACKGROUND: H1/IC31® is a tuberculosis (TB) subunit vaccine candidate consisting of the fusion protein of Ag85B and ESAT-6 (H1) formulated with the IC31® adjuvant. Previous trials have reported on the H1/IC31® vaccine in M. tuberculosis (Mtb)-naïve, BCG-vaccinated and previously Mtb-infected individ...

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Detalles Bibliográficos
Autores principales:	Hussein, Jemal, Zewdie, Martha, Yamuah, Lawrence, Bedru, Ahmed, Abebe, Markos, Dagnew, Alemnew F., Chanyalew, Menberework, Yohannes, Asfawesen G., Ahmed, Jemal, Engers, Howard, Doherty, T. Mark, Bang, Peter, Kromann, Ingrid, Hoff, Søren T., Aseffa, Abraham
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764015/ https://www.ncbi.nlm.nih.gov/pubmed/29321075 http://dx.doi.org/10.1186/s13063-017-2354-0

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