Calcium phosphate cements for bone engineering and their biological properties

Calcium phosphate cements (CPCs) are frequently used to repair bone defects. Since their discovery in the 1980s, extensive research has been conducted to improve their properties, and emerging evidence supports their increased application in bone tissue engineering. Much effort has been made to enha...

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Autores principales: Xu, Hockin HK, Wang, Ping, Wang, Lin, Bao, Chongyun, Chen, Qianming, Weir, Michael D, Chow, Laurence C, Zhao, Liang, Zhou, Xuedong, Reynolds, Mark A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764120/
https://www.ncbi.nlm.nih.gov/pubmed/29354304
http://dx.doi.org/10.1038/boneres.2017.56
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author Xu, Hockin HK
Wang, Ping
Wang, Lin
Bao, Chongyun
Chen, Qianming
Weir, Michael D
Chow, Laurence C
Zhao, Liang
Zhou, Xuedong
Reynolds, Mark A
author_facet Xu, Hockin HK
Wang, Ping
Wang, Lin
Bao, Chongyun
Chen, Qianming
Weir, Michael D
Chow, Laurence C
Zhao, Liang
Zhou, Xuedong
Reynolds, Mark A
author_sort Xu, Hockin HK
collection PubMed
description Calcium phosphate cements (CPCs) are frequently used to repair bone defects. Since their discovery in the 1980s, extensive research has been conducted to improve their properties, and emerging evidence supports their increased application in bone tissue engineering. Much effort has been made to enhance the biological performance of CPCs, including their biocompatibility, osteoconductivity, osteoinductivity, biodegradability, bioactivity, and interactions with cells. This review article focuses on the major recent developments in CPCs, including 3D printing, injectability, stem cell delivery, growth factor and drug delivery, and pre-vascularization of CPC scaffolds via co-culture and tri-culture techniques to enhance angiogenesis and osteogenesis.
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spelling pubmed-57641202018-01-19 Calcium phosphate cements for bone engineering and their biological properties Xu, Hockin HK Wang, Ping Wang, Lin Bao, Chongyun Chen, Qianming Weir, Michael D Chow, Laurence C Zhao, Liang Zhou, Xuedong Reynolds, Mark A Bone Res Review Article Calcium phosphate cements (CPCs) are frequently used to repair bone defects. Since their discovery in the 1980s, extensive research has been conducted to improve their properties, and emerging evidence supports their increased application in bone tissue engineering. Much effort has been made to enhance the biological performance of CPCs, including their biocompatibility, osteoconductivity, osteoinductivity, biodegradability, bioactivity, and interactions with cells. This review article focuses on the major recent developments in CPCs, including 3D printing, injectability, stem cell delivery, growth factor and drug delivery, and pre-vascularization of CPC scaffolds via co-culture and tri-culture techniques to enhance angiogenesis and osteogenesis. Nature Publishing Group 2017-12-20 /pmc/articles/PMC5764120/ /pubmed/29354304 http://dx.doi.org/10.1038/boneres.2017.56 Text en Copyright © 2017 The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Review Article
Xu, Hockin HK
Wang, Ping
Wang, Lin
Bao, Chongyun
Chen, Qianming
Weir, Michael D
Chow, Laurence C
Zhao, Liang
Zhou, Xuedong
Reynolds, Mark A
Calcium phosphate cements for bone engineering and their biological properties
title Calcium phosphate cements for bone engineering and their biological properties
title_full Calcium phosphate cements for bone engineering and their biological properties
title_fullStr Calcium phosphate cements for bone engineering and their biological properties
title_full_unstemmed Calcium phosphate cements for bone engineering and their biological properties
title_short Calcium phosphate cements for bone engineering and their biological properties
title_sort calcium phosphate cements for bone engineering and their biological properties
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764120/
https://www.ncbi.nlm.nih.gov/pubmed/29354304
http://dx.doi.org/10.1038/boneres.2017.56
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