Does HLA-B27 Status Influence Ankylosing Spondylitis Phenotype?

The association of HLA-B27 with ankylosing spondylitis (AS) remains as one of the intriguing models that could exist between a molecule and human disease in medicine. Although it was reported in 1973, its contribution to AS and related spondyloarthritis continues to be a major challenge for scientif...

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Detalles Bibliográficos
Autores principales: Akassou, Amal, Bakri, Youssef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764146/
https://www.ncbi.nlm.nih.gov/pubmed/29343996
http://dx.doi.org/10.1177/1179544117751627
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author Akassou, Amal
Bakri, Youssef
author_facet Akassou, Amal
Bakri, Youssef
author_sort Akassou, Amal
collection PubMed
description The association of HLA-B27 with ankylosing spondylitis (AS) remains as one of the intriguing models that could exist between a molecule and human disease in medicine. Although it was reported in 1973, its contribution to AS and related spondyloarthritis continues to be a major challenge for scientific community. It is important to understand its etiopathogenic mechanism and its functions in these diseases. Although the diagnostic and prognostic roles of HLA-B27 in AS are still debated, there is an increasing interest for HLA-B27–based effects especially in HLA-B27(+) patients with AS. This review will focus in the examination of published reports regarding the influence of HLA-B27 status on the demographic and clinical features in AS, with specific interest to its role on AS severity.
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spelling pubmed-57641462018-01-17 Does HLA-B27 Status Influence Ankylosing Spondylitis Phenotype? Akassou, Amal Bakri, Youssef Clin Med Insights Arthritis Musculoskelet Disord Review The association of HLA-B27 with ankylosing spondylitis (AS) remains as one of the intriguing models that could exist between a molecule and human disease in medicine. Although it was reported in 1973, its contribution to AS and related spondyloarthritis continues to be a major challenge for scientific community. It is important to understand its etiopathogenic mechanism and its functions in these diseases. Although the diagnostic and prognostic roles of HLA-B27 in AS are still debated, there is an increasing interest for HLA-B27–based effects especially in HLA-B27(+) patients with AS. This review will focus in the examination of published reports regarding the influence of HLA-B27 status on the demographic and clinical features in AS, with specific interest to its role on AS severity. SAGE Publications 2018-01-08 /pmc/articles/PMC5764146/ /pubmed/29343996 http://dx.doi.org/10.1177/1179544117751627 Text en © The Author(s) 2018 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Akassou, Amal
Bakri, Youssef
Does HLA-B27 Status Influence Ankylosing Spondylitis Phenotype?
title Does HLA-B27 Status Influence Ankylosing Spondylitis Phenotype?
title_full Does HLA-B27 Status Influence Ankylosing Spondylitis Phenotype?
title_fullStr Does HLA-B27 Status Influence Ankylosing Spondylitis Phenotype?
title_full_unstemmed Does HLA-B27 Status Influence Ankylosing Spondylitis Phenotype?
title_short Does HLA-B27 Status Influence Ankylosing Spondylitis Phenotype?
title_sort does hla-b27 status influence ankylosing spondylitis phenotype?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764146/
https://www.ncbi.nlm.nih.gov/pubmed/29343996
http://dx.doi.org/10.1177/1179544117751627
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