Insulin and branched-chain amino acid depletion during mouse preimplantation embryo culture programmes body weight gain and raised blood pressure during early postnatal life

Mouse maternal low protein diet exclusively during preimplantation development (Emb-LPD) is sufficient to programme altered growth and cardiovascular dysfunction in offspring. Here, we use an in vitro model comprising preimplantation culture in medium depleted in insulin and branched-chain amino aci...

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Detalles Bibliográficos
Autores principales: Velazquez, Miguel A., Sheth, Bhavwanti, Smith, Stephanie J., Eckert, Judith J., Osmond, Clive, Fleming, Tom P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Pub. Co 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764225/
https://www.ncbi.nlm.nih.gov/pubmed/29196239
http://dx.doi.org/10.1016/j.bbadis.2017.11.020

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