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Sexually dimorphic effects of dietary sugar on lifespan, feeding and starvation resistance in Drosophila
Lifespan and health in older age are strongly influenced by diet. Feeding Drosophila melanogaster diets high in sugar has increasingly been used as an experimental model to understand the physiological effects of unhealthy, contemporary human diets. Several metabolic parameters and physiological res...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764390/ https://www.ncbi.nlm.nih.gov/pubmed/29207375 http://dx.doi.org/10.18632/aging.101335 |
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author | Chandegra, Bhakti Tang, Jocelyn Lok Yee Chi, Haoyu Alic, Nazif |
author_facet | Chandegra, Bhakti Tang, Jocelyn Lok Yee Chi, Haoyu Alic, Nazif |
author_sort | Chandegra, Bhakti |
collection | PubMed |
description | Lifespan and health in older age are strongly influenced by diet. Feeding Drosophila melanogaster diets high in sugar has increasingly been used as an experimental model to understand the physiological effects of unhealthy, contemporary human diets. Several metabolic parameters and physiological responses to nutrition are known to be dependent on the sex of the animal. However, sexual dimorphism in the responses to high-sugar diets in fruit flies has not been examined. Here we show that a high-sugar diet in Drosophila melanogaster elicits sexually dimorphic effects on feeding behaviour, starvation resistance and lifespan. Females feed less on such diets, while males feed more, and these feeding responses may have secondary consequences. Females, more than males, gain the ability to resist periods of starvation from high-sugar diets, indicating that the female response to excess sugar may be geared towards surviving food shortages in early life. At the same time, female lifespan is more susceptible to the detrimental effects of high sugar diets. Our study reveals differences between Drosophila sexes in their responses to sugar-rich diets, indicating the fruit fly could be used as a model to understand the sexually dimorphic features of human metabolic health. |
format | Online Article Text |
id | pubmed-5764390 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-57643902018-01-14 Sexually dimorphic effects of dietary sugar on lifespan, feeding and starvation resistance in Drosophila Chandegra, Bhakti Tang, Jocelyn Lok Yee Chi, Haoyu Alic, Nazif Aging (Albany NY) Research Paper Lifespan and health in older age are strongly influenced by diet. Feeding Drosophila melanogaster diets high in sugar has increasingly been used as an experimental model to understand the physiological effects of unhealthy, contemporary human diets. Several metabolic parameters and physiological responses to nutrition are known to be dependent on the sex of the animal. However, sexual dimorphism in the responses to high-sugar diets in fruit flies has not been examined. Here we show that a high-sugar diet in Drosophila melanogaster elicits sexually dimorphic effects on feeding behaviour, starvation resistance and lifespan. Females feed less on such diets, while males feed more, and these feeding responses may have secondary consequences. Females, more than males, gain the ability to resist periods of starvation from high-sugar diets, indicating that the female response to excess sugar may be geared towards surviving food shortages in early life. At the same time, female lifespan is more susceptible to the detrimental effects of high sugar diets. Our study reveals differences between Drosophila sexes in their responses to sugar-rich diets, indicating the fruit fly could be used as a model to understand the sexually dimorphic features of human metabolic health. Impact Journals LLC 2017-12-04 /pmc/articles/PMC5764390/ /pubmed/29207375 http://dx.doi.org/10.18632/aging.101335 Text en Copyright: © 2017 Chandegra et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Research Paper Chandegra, Bhakti Tang, Jocelyn Lok Yee Chi, Haoyu Alic, Nazif Sexually dimorphic effects of dietary sugar on lifespan, feeding and starvation resistance in Drosophila |
title | Sexually dimorphic effects of dietary sugar on lifespan, feeding and starvation resistance in Drosophila |
title_full | Sexually dimorphic effects of dietary sugar on lifespan, feeding and starvation resistance in Drosophila |
title_fullStr | Sexually dimorphic effects of dietary sugar on lifespan, feeding and starvation resistance in Drosophila |
title_full_unstemmed | Sexually dimorphic effects of dietary sugar on lifespan, feeding and starvation resistance in Drosophila |
title_short | Sexually dimorphic effects of dietary sugar on lifespan, feeding and starvation resistance in Drosophila |
title_sort | sexually dimorphic effects of dietary sugar on lifespan, feeding and starvation resistance in drosophila |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764390/ https://www.ncbi.nlm.nih.gov/pubmed/29207375 http://dx.doi.org/10.18632/aging.101335 |
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