Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening

Leishmaniasis is a parasitic infection that afflicts approximately 12 million people worldwide. There are several limitations to the approved drug therapies for leishmaniasis, including moderate to severe toxicity, growing drug resistance, and the need for extended dosing. Moreover, miltefosine is c...

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Detalles Bibliográficos
Autores principales: Ortiz, Diana, Guiguemde, W. Armand, Hammill, Jared T., Carrillo, Angela K., Chen, Yizhe, Connelly, Michele, Stalheim, Kayla, Elya, Carolyn, Johnson, Alex, Min, Jaeki, Shelat, Anang, Smithson, David C., Yang, Lei, Zhu, Fangyi, Guy, R. Kiplin, Landfear, Scott M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764437/
https://www.ncbi.nlm.nih.gov/pubmed/29287089
http://dx.doi.org/10.1371/journal.pntd.0006157

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