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Sculpting ion channel functional expression with engineered ubiquitin ligases

The functional repertoire of surface ion channels is sustained by dynamic processes of trafficking, sorting, and degradation. Dysregulation of these processes underlies diverse ion channelopathies including cardiac arrhythmias and cystic fibrosis. Ubiquitination powerfully regulates multiple steps i...

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Detalles Bibliográficos
Autores principales:	Kanner, Scott A, Morgenstern, Travis, Colecraft, Henry M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764571/ https://www.ncbi.nlm.nih.gov/pubmed/29256394 http://dx.doi.org/10.7554/eLife.29744

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