Impaired autophagy bridges lysosomal storage disease and epithelial dysfunction in the kidney

The endolysosomal system sustains the reabsorptive activity of specialized epithelial cells. Lysosomal storage diseases such as nephropathic cystinosis cause a major dysfunction of epithelial cells lining the kidney tubule, resulting in massive losses of vital solutes in the urine. The mechanisms li...

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Detalles Bibliográficos
Autores principales: Festa, Beatrice Paola, Chen, Zhiyong, Berquez, Marine, Debaix, Huguette, Tokonami, Natsuko, Prange, Jenny Ann, Hoek, Glenn van de, Alessio, Cremonesi, Raimondi, Andrea, Nevo, Nathalie, Giles, Rachel H., Devuyst, Olivier, Luciani, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765140/
https://www.ncbi.nlm.nih.gov/pubmed/29323117
http://dx.doi.org/10.1038/s41467-017-02536-7

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