New anti-inflammatory guaianes from the Atlantic hydrotherm-derived fungus Graphostroma sp. MCCC 3A00421

Nine new guaianes (graphostromanes A–I, 1–9) were isolated from the deep-sea-derived fungus Graphostroma sp. MCCC 3A00421, along with four known ones (10–13). The relative configurations were established mainly by detailed analysis of the NMR and HRESIMS data, while the absolute configurations were...

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Detalles Bibliográficos
Autores principales: Niu, Siwen, Xie, Chun-Lan, Xia, Jin-Mei, Luo, Zhu-Hua, Shao, Zongze, Yang, Xian-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765142/
https://www.ncbi.nlm.nih.gov/pubmed/29323171
http://dx.doi.org/10.1038/s41598-017-18841-6
Descripción
Sumario:Nine new guaianes (graphostromanes A–I, 1–9) were isolated from the deep-sea-derived fungus Graphostroma sp. MCCC 3A00421, along with four known ones (10–13). The relative configurations were established mainly by detailed analysis of the NMR and HRESIMS data, while the absolute configurations were assigned using the X-ray crystallography and modified Mosher’s method. All isolates were evaluated for their inhibitory effects against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages. Graphostromanes F (6) showed remarkable inhibitory effect with an IC(50) value of 14.2 μM, which was even stronger than that of aminoguanidine, a positive control with an IC(50) value of 23.4 μM.

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