New anti-inflammatory guaianes from the Atlantic hydrotherm-derived fungus Graphostroma sp. MCCC 3A00421

Nine new guaianes (graphostromanes A–I, 1–9) were isolated from the deep-sea-derived fungus Graphostroma sp. MCCC 3A00421, along with four known ones (10–13). The relative configurations were established mainly by detailed analysis of the NMR and HRESIMS data, while the absolute configurations were...

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Autores principales: Niu, Siwen, Xie, Chun-Lan, Xia, Jin-Mei, Luo, Zhu-Hua, Shao, Zongze, Yang, Xian-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765142/
https://www.ncbi.nlm.nih.gov/pubmed/29323171
http://dx.doi.org/10.1038/s41598-017-18841-6
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author Niu, Siwen
Xie, Chun-Lan
Xia, Jin-Mei
Luo, Zhu-Hua
Shao, Zongze
Yang, Xian-Wen
author_facet Niu, Siwen
Xie, Chun-Lan
Xia, Jin-Mei
Luo, Zhu-Hua
Shao, Zongze
Yang, Xian-Wen
author_sort Niu, Siwen
collection PubMed
description Nine new guaianes (graphostromanes A–I, 1–9) were isolated from the deep-sea-derived fungus Graphostroma sp. MCCC 3A00421, along with four known ones (10–13). The relative configurations were established mainly by detailed analysis of the NMR and HRESIMS data, while the absolute configurations were assigned using the X-ray crystallography and modified Mosher’s method. All isolates were evaluated for their inhibitory effects against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages. Graphostromanes F (6) showed remarkable inhibitory effect with an IC(50) value of 14.2 μM, which was even stronger than that of aminoguanidine, a positive control with an IC(50) value of 23.4 μM.
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spelling pubmed-57651422018-01-17 New anti-inflammatory guaianes from the Atlantic hydrotherm-derived fungus Graphostroma sp. MCCC 3A00421 Niu, Siwen Xie, Chun-Lan Xia, Jin-Mei Luo, Zhu-Hua Shao, Zongze Yang, Xian-Wen Sci Rep Article Nine new guaianes (graphostromanes A–I, 1–9) were isolated from the deep-sea-derived fungus Graphostroma sp. MCCC 3A00421, along with four known ones (10–13). The relative configurations were established mainly by detailed analysis of the NMR and HRESIMS data, while the absolute configurations were assigned using the X-ray crystallography and modified Mosher’s method. All isolates were evaluated for their inhibitory effects against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages. Graphostromanes F (6) showed remarkable inhibitory effect with an IC(50) value of 14.2 μM, which was even stronger than that of aminoguanidine, a positive control with an IC(50) value of 23.4 μM. Nature Publishing Group UK 2018-01-11 /pmc/articles/PMC5765142/ /pubmed/29323171 http://dx.doi.org/10.1038/s41598-017-18841-6 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Niu, Siwen
Xie, Chun-Lan
Xia, Jin-Mei
Luo, Zhu-Hua
Shao, Zongze
Yang, Xian-Wen
New anti-inflammatory guaianes from the Atlantic hydrotherm-derived fungus Graphostroma sp. MCCC 3A00421
title New anti-inflammatory guaianes from the Atlantic hydrotherm-derived fungus Graphostroma sp. MCCC 3A00421
title_full New anti-inflammatory guaianes from the Atlantic hydrotherm-derived fungus Graphostroma sp. MCCC 3A00421
title_fullStr New anti-inflammatory guaianes from the Atlantic hydrotherm-derived fungus Graphostroma sp. MCCC 3A00421
title_full_unstemmed New anti-inflammatory guaianes from the Atlantic hydrotherm-derived fungus Graphostroma sp. MCCC 3A00421
title_short New anti-inflammatory guaianes from the Atlantic hydrotherm-derived fungus Graphostroma sp. MCCC 3A00421
title_sort new anti-inflammatory guaianes from the atlantic hydrotherm-derived fungus graphostroma sp. mccc 3a00421
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765142/
https://www.ncbi.nlm.nih.gov/pubmed/29323171
http://dx.doi.org/10.1038/s41598-017-18841-6
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