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Mice deficient in the Shmt2 gene have mitochondrial respiration defects and are embryonic lethal

Accumulation of somatic mutations in mitochondrial DNA (mtDNA) has been proposed to be responsible for human aging and age-associated mitochondrial respiration defects. However, our previous findings suggested an alternative hypothesis of human aging—that epigenetic changes but not mutations regulat...

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Detalles Bibliográficos
Autores principales: Tani, Haruna, Ohnishi, Sakiko, Shitara, Hiroshi, Mito, Takayuki, Yamaguchi, Midori, Yonekawa, Hiromichi, Hashizume, Osamu, Ishikawa, Kaori, Nakada, Kazuto, Hayashi, Jun-Ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765156/
https://www.ncbi.nlm.nih.gov/pubmed/29323231
http://dx.doi.org/10.1038/s41598-017-18828-3

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