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Developmentally regulated signaling pathways in glioma invasion
Malignant gliomas are the most common, infiltrative, and lethal primary brain tumors affecting the adult population. The grim prognosis for this disease is due to a combination of the presence of highly invasive tumor cells that escape surgical resection and the presence of a population of therapy-r...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765207/ https://www.ncbi.nlm.nih.gov/pubmed/28821904 http://dx.doi.org/10.1007/s00018-017-2608-8 |
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author | Mehta, Shwetal Lo Cascio, Costanza |
author_facet | Mehta, Shwetal Lo Cascio, Costanza |
author_sort | Mehta, Shwetal |
collection | PubMed |
description | Malignant gliomas are the most common, infiltrative, and lethal primary brain tumors affecting the adult population. The grim prognosis for this disease is due to a combination of the presence of highly invasive tumor cells that escape surgical resection and the presence of a population of therapy-resistant cancer stem cells found within these tumors. Several studies suggest that glioma cells have cleverly hijacked the normal developmental program of neural progenitor cells, including their transcriptional programs, to enhance gliomagenesis. In this review, we summarize the role of developmentally regulated signaling pathways that have been found to facilitate glioma growth and invasion. Furthermore, we discuss how the microenvironment and treatment-induced perturbations of these highly interconnected signaling networks can trigger a shift in cellular phenotype and tumor subtype. |
format | Online Article Text |
id | pubmed-5765207 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-57652072018-01-25 Developmentally regulated signaling pathways in glioma invasion Mehta, Shwetal Lo Cascio, Costanza Cell Mol Life Sci Review Malignant gliomas are the most common, infiltrative, and lethal primary brain tumors affecting the adult population. The grim prognosis for this disease is due to a combination of the presence of highly invasive tumor cells that escape surgical resection and the presence of a population of therapy-resistant cancer stem cells found within these tumors. Several studies suggest that glioma cells have cleverly hijacked the normal developmental program of neural progenitor cells, including their transcriptional programs, to enhance gliomagenesis. In this review, we summarize the role of developmentally regulated signaling pathways that have been found to facilitate glioma growth and invasion. Furthermore, we discuss how the microenvironment and treatment-induced perturbations of these highly interconnected signaling networks can trigger a shift in cellular phenotype and tumor subtype. Springer International Publishing 2017-08-18 2018 /pmc/articles/PMC5765207/ /pubmed/28821904 http://dx.doi.org/10.1007/s00018-017-2608-8 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Review Mehta, Shwetal Lo Cascio, Costanza Developmentally regulated signaling pathways in glioma invasion |
title | Developmentally regulated signaling pathways in glioma invasion |
title_full | Developmentally regulated signaling pathways in glioma invasion |
title_fullStr | Developmentally regulated signaling pathways in glioma invasion |
title_full_unstemmed | Developmentally regulated signaling pathways in glioma invasion |
title_short | Developmentally regulated signaling pathways in glioma invasion |
title_sort | developmentally regulated signaling pathways in glioma invasion |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765207/ https://www.ncbi.nlm.nih.gov/pubmed/28821904 http://dx.doi.org/10.1007/s00018-017-2608-8 |
work_keys_str_mv | AT mehtashwetal developmentallyregulatedsignalingpathwaysingliomainvasion AT locasciocostanza developmentallyregulatedsignalingpathwaysingliomainvasion |