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Targeting the Raf kinases in human cancer: the Raf dimer dilemma
The Raf protein kinases are key intermediates in cellular signal transduction, functioning as direct effectors of the Ras GTPases and as the initiating kinases in the ERK cascade. In human cancer, Raf activity is frequently dysregulated due to mutations in the Raf family member B-Raf or to alteratio...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765234/ https://www.ncbi.nlm.nih.gov/pubmed/29235562 http://dx.doi.org/10.1038/bjc.2017.399 |